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Ocular Transporters in Ophthalmic Diseases and Drug Delivery
Par Colin J. Barnstable, Joyce Tombran-Tink. 2008
In this exceptionally important new work, a panel of distinguished authors discusses all the latest developments in the study of…
ocular transporters. Focusing on the molecular characteristics, localization, and substrate specificities in various compartments of the eye, this volume discusses how transporters regulate the clarity of the cornea and lens, the movements of fluids across the ciliary epithelium and nutrients across the retinal pigment epithelium.Vision Research Protocols
Par P. Elizabeth Rakoczy. 2001
Elizabeth Rakcozy and a team of leading clinical and experimental scientists describe in step-by-step detail the key techniques essential to…
effective molecular biological research in ophthalmology and optometry. These readily reproducible methods are adapted to the special requirements of vision research, with coverage that ranges from the most basic to the most sophisticated technologies. Included are methods for the down-regulation of gene expression, new gene therapy techniques, and for the development of transgenic and knockout animal models for testing novel therapies. Eminently accessible and clinically relevant, Vision Research Protocols provides experimental and biomedical investigators in ophthalmology and optometry with a rich panoply of most powerful tools with which to ask--and answer--all the important questions emerging from the dramatically advancing work in vision research today.Studies on Retinal and Choroidal Disorders
Par Thomas W. Gardner, Robert D. Stratton, William W. Hauswirth. 1984
Studies on Retinal and Choroidal Disorders examines the role that oxidative and nitrosative stress plays in the complex physiology and…
pathophysiology of the retina and choroid. Both the basic science researcher and the clinical practitioner can use this book as a guide to the current understanding of retinal and choroidal cellular mechanisms involved in aging and disease. Beginning with a review of oxidative stress and inflammation in the pathoetiology of AMD and a review of the complement system in the retina, the book then takes a detailed look at oxidative stress in lipid metabolism and oxidized lipoproteins in the retina. It examines the anti-apoptotic activity of α-crystallins in the presence of glutathione, oxidative stress in the mitochondria and endoplasmic reticulum, the role of iron in retinal disease, the mechanisms of pathological VEGF expression, NAPDH oxidase mechanisms, and Hepatocyte Growth Factor in oxidative stress in the retina. A detailed look at the Ccl2-/-/Cx3cr1-/- mouse model of AMD follows. Then a detailed examination of the systemic changes in AMD is followed by a discussion of cerium oxide nanoparticle reduction of oxidative stress. Two chapters discuss progenitor cells in the cause and treatment of retinal diseases including AMD and diabetic retinopathy. Natural compounds in the prevention and treatment of retinal diseases are exhaustively presented, followed by a chapter on serotonin 5-HT1A receptor agonists in oxidative stress of the retina. The current anti-VEGF treatment strategies of neovascular AMD are then given. The volume continues with a detailed look at nitric oxide and inducible nitric oxide synthase in retinal vascular disease, an explanation of an in vivo technique of studying the effect of lipid hydroperoxides on circulating leucocytes in the retina, an excellent review of oxidative stress in retinopathy of prematurity, and a look at VEGF induced oxidative stress in the retinal ganglion cell. The book ends with a detail examination of the role of carotenoids in retinal health and disease. These 31 chapters summarize what is known about oxidative stress in retinal and choroidal disorders. All those involved with degenerative diseases of the eye will find Studies on Retinal and Choroidal Disorders to be illuminating and comprehensive.Visual Dysfunction in Diabetes
Par Colin J. Barnstable, Joyce Tombran-Tink, Thomas W. Gardner. 2012
An exciting contribution to the field, Visual Dysfunction in Diabetes: The Science of Patient Impairment and Improvement is designed with…
two overriding objectives: to help readers understand the impact of vision impairment in people living daily with diabetes rather than considering diabetic retinopathy solely as a medical problem, and to explore what we know and don't know about the ways diabetes affect the eye. With the plethora of new information being generated, there are still a series of fundamental questions that must be addressed if effective treatments for diabetic retinopathy are to be found and applied. Developed by a renowned group of authorities, Visual Dysfunction in Diabetes: The Science of Patient Impairment and Improvement offers responses and context for a range of questions, such as: do metabolic factors beyond glucose contribute to vision-threatening diabetic retinopathy? If so, how do these lead to vision impairment? Is diabetic retinopathy a response to systemic metabolic abnormalities or are there unique ocular problems related to insulin resistance? What is the relationship between the neural, vascular, and inflammatory abnormalities in diabetic retinopathy? Do they represent a pathological cascade induced sequentially or simultaneous responses to one or more metabolic perturbations? The authors note that if we do not address these types of questions, it is possible that the long process of developing new therapeutics will target only one arm of the pathology and leave the retina open to damaging consequences of the others. State-of-the-art, comprehensive, and an invaluable addition the research and clinical literature, Visual Dysfunction in Diabetes: The Science of Patient Impairment and Improvement offers guidance and a significant step toward new scientific approaches that can lessen the devastating vision impairment associated with diabetes.Herpes Simplex Virus Epithelial Keratitis
Par Helena M. Tabery. 2010
This book on Herpes Simplex Virus Epithelial Keratitis shows a kind of 'living histology', revealing both morphological and dynamic features…
of the disease, and explaining mechanisms behind them. It offers great insights helpful for the differential diagnostics and the recognition of less known variants as well as of complications. It is also highly useful for the follow-up of treatment results and the differentiation between an active infection and sequelae. Thus, this book will be an invaluable aid for ophthalmologists and researchers working with ocular surface diseases.The Male Patient in Aesthetic Medicine
Par Berthold Rzany, Mauricio De Maio. 2009
The demand for cosmetic procedures by male patients has increased in recent years. With this trend has come the realization…
that male aesthetic needs are different from female aesthetic needs. This book is the first hands-on guide dedicated exclusively to the aesthetic treatment of the male patient, and provides cosmetic surgeons with important information on how to obtain a natural male look for such patients. It explains facial aesthetics and the aging process in men, as well as the current aesthetic medicine techniques available. It also offers valuable strategies for avoiding and treating undesired results. Written by internationally known experts in the field, this unique guide enables cosmetic surgeons to achieve the best possible treatment outcomes, as well as increased satisfaction in male patients.The Untold History of Healing: Plant Lore and Medicinal Magic from the Stone Age to Present
Par Wolf D. Storl. 2017
The Untold History of Healing takes the reader on a exciting, expansive journey of the history of medicine from the…
Stone Age to modern times, explaining that Western medicine has its true origins in the healing lore of Paleolithic hunters and gatherers, herding nomads, and the early sedentary farmers rather than in the academic tradition of doctors and pharmacists. This absorbing history of medicine takes the reader on a sweeping journey from the Stone Age to modern times, showing that Western medicine has its origins not only in the academic tradition of doctors and pharmacists, but in the healing lore of Paleolithic hunters and gatherers, herding nomads, and the early sedentary farmers. Anthropologist and ethnobotanist Wolf D. Storl vividly describes the many ways that ancient peoples have used the plants in their immediate environment, along with handed-down knowledge and traditions, to treat the variety of ailments they encountered in daily life.Vitreous
Par J. Sebag. 2014
The vitreous body long has been the most mysterious of all ocular structures, owing perhaps to its seeming simplicity. There…
have been few concerted, sustained efforts to unravel the mysteries of how vitreous is composed and what role it plays in normal physiology as well as pathology. Over the years, however, many studies have produced important findings concerning vitreous biochemistry, structure, physiology, and pathobiology. Published on the 25th anniversary of Sebag's first book on Vitreous, this second installment is nearly five times longer than its predecessor, reflecting how much has been learned in the past quarter century. This well-constructed compendium not only addresses the most current scientific knowledge, but also reviews clinical perspectives in a manner that lends richness to the scope of the book. Written by 90 authors, this book has 56 chapters organized into 7 sections: Biochemistry; Anatomy, Development, and Aging; Pathology/Pathobiology; Physiology and Phamacotherapy; Posterior Vitreo-Retinal Surgery; Peripheral Vitreo-Retinal Surgery; and Pharmacologic Vitreolysis. With a foreword by Coleman & Lincoff and an introduction by Wallace Foulds, Sebag's latest tome on vitreous is destined to be the authoritative text for years to come.Uveitis
Par George N. Papaliodis. 2017
Uveitis is a practical guide for the diagnosis and treatment of uveitis and ocular inflammatory diseases. This text provides uveitis…
specialists, practicing ophthalmologists, and ophthalmology residents with the appropriate diagnostic testing and evidenced-based therapeutic options for managing patients afflicted with these conditions. The realm of ocular inflammatory diseases is constantly changing with improved diagnostic modalities and treatment options, however, despite these innovations, the ocular inflammatory diseases, including uveitis, are the third leading cause of blindness worldwide. Written and edited by leaders in the fields of ophthalmology, rheumatology, internal medicine, infectious disease, and oncology, Uveitis addresses the latest advances in the field, from the advent of PCR technology, intraocular depot steroid implants, neoplastic and infectious diseases masquerading as uveitis, and the use of systemic immunomoduatory therapies (including biologic agents/humanized monoclonal antibodies in the armamentarium).Dark Shamans: Kanaimà and the Poetics of Violent Death
Par Neil L. Whitehead. 2002
On the little-known and darker side of shamanism there exists an ancient form of sorcery called kanaimà, a practice still…
observed among the Amerindians of the highlands of Guyana, Venezuela, and Brazil that involves the ritual stalking, mutilation, lingering death, and consumption of human victims. At once a memoir of cultural encounter and an ethnographic and historical investigation, this book offers a sustained, intimate look at kanaimà, its practitioners, their victims, and the reasons they give for their actions. Neil L. Whitehead tells of his own involvement with kanaimà--including an attempt to kill him with poison--and relates the personal testimonies of kanaimà shamans, their potential victims, and the victims' families. He then goes on to discuss the historical emergence of kanaimà, describing how, in the face of successive modern colonizing forces--missionaries, rubber gatherers, miners, and development agencies--the practice has become an assertion of native autonomy. His analysis explores the ways in which kanaimà mediates both national and international impacts on native peoples in the region and considers the significance of kanaimà for current accounts of shamanism and religious belief and for theories of war and violence. Kanaimà appears here as part of the wider lexicon of rebellious terror and exotic horror--alongside the cannibal, vampire, and zombie--that haunts the western imagination. Dark Shamans broadens discussions of violence and of the representation of primitive savagery by recasting both in the light of current debates on modernity and globalization.The Encyclopedia of Magickal Ingredients
Par Lexa Rosean. 2005
Bringing the art and magick of casting spells to the masses, Lexa Rosean is the new face of Wicca. In…
The Encyclopedia of Magickal Ingredients she provides beginner and experienced practitioners of spellcasting with a quick, easy, and accurate guide to the magickal powers and properties of herbs, spices, flowers, vegetables, fruits, metals, and colors -- more than 500 ingredients in all. With this info at your fingertips, you can craft spells for specific desires or needs -- whether it's love, luck, fertility, or even next month's rent! Written with passion for the craft and a deep understanding of the needs of modern-day Wiccans, The Encyclopedia of Magickal Ingredients is an indispensable addition to every occult library and an essential reference for all with the gift of magick.The Ecstatic Experience: Healing Postures for Spirit Journeys
Par Belinda Gore. 2009
Trance-inducing postures for shamanic journeying, initiation, healing, divination, and transformation of the soul • Provides practices from Mayan, Egyptian, African,…
Native American, Sumerian, and other ancient and indigenous traditions • Shows how these practices can detoxify the energy body The human need for ecstasy--the ability to be free of the limitations of ordinary consciousness--is as imperative as the need for food. Renowned anthropologist Felicitas Goodman claimed that being deprived of ecstasy was the fundamental cause of all forms of addiction. Indigenous cultures and the civilizations of antiquity were aware of this and developed specific rituals to induce and channel trance energies to detoxify and nourish the subtle body in order to experience the ecstatic reality that gives life to matter. The body postures seen in ancient art from Mayan, Egyptian, African, Native American, Sumerian, and other ancient and indigenous traditions are a doorway to inducing this kind of ecstatic trance. People who assume these postures in a ritual context are able to experience expanded and transformative states of consciousness. Following up on the groundbreaking introduction of this practice in her first book, Ecstatic Body Postures, Belinda Gore provides a new series of 20 sacred postures and exercises that allow for a deeper understanding and utilization of these shamanic practices. She shows how to use the energy awakened by these practices for healing, shapeshifting, initiations into the mysteries of death and rebirth, divination, spirit journeying, and restoring balance to the cosmic patterns disrupted by destructive human activity.Small-Gauge Vitrectomy for Diabetic Retinopathy
Par Ulrich Spandau, Zoran Tomic. 2015
This book describes step by step how to operate on the patient with diabetic retinopathy. After thorough explanation of surgical…
planning, including the potential need to perform individual procedures at different time points, each stage of the vitrectomy is clearly documented with the aid of color photographs and drawings as well as online surgical videos. Variations in approach are described that are potentially of value, depending on whether one is dealing with a straightforward diabetic retinopathy or a difficult case of tractional retinal detachment. In the second part of the book, a series of case reports are presented that illustrate the surgical procedures applicable in different circumstances. In addition, pearls and pitfalls are highlighted. Small-Gauge Vitrectomy for Diabetic Retinopathy will be an ideal source of information and guidance for all who are embarking upon such surgery or wish to further hone their skills.Ema's Odyssey
Par Michael Harner, Sandra Harner. 2014
Follow the fantastic odyssey of one woman as she explores shamanic realms, encountering spirit animals and other teachers who answer…
her deepest questions and provide her with life-changing guidance and healing. Widowed, childless, and alone, 60-year-old Ema bravely decides to expand her self-knowledge by embarking on a spiritual adventure. She meets with author Sandra Harner, who leads her through five sessions of Harner Shamanic Counseling (HSC), a highly effective system of personal problem-solving in which counselors help clients enter a shamanic state of consciousness using a specific sonic rhythm. While in this state, clients seek out helping spirits, who offer insight, wisdom, and healing. By the end of her sessions with Harner, Ema has discovered her own innate ability to find answers to pervasive personal questions, overcome inhibitory fears, and acquire self-confidence and wisdom. She has found a sense of personal empowerment and a newfound joy in existence--and decides she wants to continue her journeys independently. From 1999 to 2011, Ema ventures on a total of 64 journeys, each one chronicled in this book, thanks to taped recordings of her simultaneous narration. In addition to serving as an invaluable resource for students and practitioners of shamanism, psychology, and alternative modalities of therapy, Ema's Odyssey enchants us with its lyrical poetry and unique wisdom, and inspires us with its demonstration of courage, curiosity, persistence, and humility. Perhaps most importantly, we come away with the added assurance that we are not alone, that there are oft-untapped resources we all can access, given the tools and trust in our own experience.From the Trade Paperback edition.Glaucoma Imaging
Par Antonio Ferreras. 2016
This atlas offers a truly comprehensive update on the use of imaging technologies for the diagnosis and follow-up of glaucoma.…
In addition to standard automated perimetry, gonioscopy, fundus photography, and stereophotography, other advanced, high-resolution methods for imaging the eye in glaucoma are explained in detail, including ultrasound biomicroscopy, confocal scanning laser ophthalmoscopy, scanning laser polarimetry, and spectral domain optical coherence tomography. The role of the various tests and the keys to optimizing their use in clinical practice are detailed with the aid of high-quality figures in order to enable the reader to achieve the best possible performance when applying these tools. The risk of developing visual disability and blindness as a consequence of glaucoma varies widely among affected individuals. Personalized testing strategies and tailored therapeutic interventions are required to effectively reduce visual impairment due to glaucoma. Glaucoma Imaging will assist residents, researchers, and clinicians in improving their ability to understand and integrate the information obtained using traditional techniques with the reports provided by computer-assisted image instruments.Pathologic Myopia
Par Richard F. Spaide, Kyoko Ohno-Matsui, Lawrence A. Yannuzzi. 2014
Pathological Myopia is a major cause of severe vision loss worldwide. The mechanisms for vision loss include cataract, glaucoma, retinal…
detachment, and above all, degeneration of the macula within the posterior staphyloma. Pathological Myopia is one of the only current books to specifically address this disease and discusses recent developments in imaging technologies and various approaches to treatments, such as laser photocoagulation, photodynamic therapy, pharmaco-therapeutic injections in the vitreous, and surgery. Complete with high-quality color images, this book is written and edited by leaders in the field and is geared towards ophthalmologists, including residents and fellows in training, glaucoma and cataract specialists, and vitreoretinal macula experts.Orbital Fractures
Par Vadim P. Nikolaenko, Yury S. Astakhov. 2015
This book thoroughly reviews the diagnosis and treatment of injuries of the orbital walls and apex, including orbital floor, medial…
orbital wall, naso-orbito-ethmoid, orbitozygomatic, maxillary, and frontobasilar fractures. For each form of injury, signs and symptoms are identified and clear guidance is provided on the interpretation of clinical and radiological findings and on current surgical treatment methods. In addition, the role of orbital imaging techniques, including CT and MRI, in depicting anatomic relations is explained with the aid of a wealth of radiological images and photographs. The described approach to fracture management is multidisciplinary in nature and the advice is evidence based, drawing on the latest published data. Orbital Fractures: A Physician's Manual will be an invaluable reference and guide for ophthalmologists, maxillofacial surgeons, neurosurgeons, otolaryngologists, radiologists, and emergency physicians. It will also be an excellent resource for all medical students, residents in ophthalmology, and fellows who wish to broaden their spectrum of knowledge in orbital pathology.Managing Complications in Glaucoma Surgery
Par Francis Carbonaro, K. Sheng Lim. 2017
This well-illustrated book is intended as the go-to guide for the identification and management of the complications associated with specific…
glaucoma procedures. All of the routinely performed procedures are covered: filtration surgery, including trabeculectomy and ExPRESS shunt, nonpenetrating surgeries such as deep sclerectomy and canaloplasty, procedures involving the placement of tube shunt devices, glaucoma laser treatments, and minimally invasive glaucoma surgeries (MIGS). The book is succinct but sufficiently detailed to provide the reader with a very well informed description of possible complications and the best way to manage them, based on the evidence from recent and seminal research. The authors are recognized experts who come from a wide geographic and varied glaucoma background. The book will be ideal for all surgeons, whether new or experienced, who seek easily accessible, reliable guidance on how to manage the intraoperative and early and late postoperative complications that may arise when performing glaucoma surgery.Keratoconjunctivitis Sicca and Filamentary Keratopathy
Par Helena M. Tabery. 2011
This book presents in vivo captured high-magnification images of two conditions: keratoconjunctivitis sicca (KCS, or dry eye), an extremely common…
disease of the ocular surface, and filamentary keratopathy, a relatively rare phenomenon most commonly associated with KCS. The images of KCS represent the broad spectrum of ocular surface changes seen in the condition while the images of filamentary keratopathy clearly reveal the components of the ocular surface appendices, termed filaments. The photographs show phenomena captured in various illumination modes, without staining and after staining with diagnostic dyes, and the photographic sequences illustrate their dynamics. The images reflect the in vivo situation. Once aware of the various phenomena, anyone working with standard diagnostic equipment - the slit lamp and the diagnostic dyes- will be able to detect almost all of them. The book will be invaluable for all who deal with ocular surface diseases.Orbital Tumors
Par Zeynel A. Karcioglu. 2015
Orbital Tumors, 2nd edition discusses advances in orbital disease and their treatment, offering readers an up-to-date, single volume reference for…
orbital tumors. Divided into two parts, this book covers everything from advances in oncogenesis and its relationship to orbital tumors, to medical genetics and the role of imaging in diagnosis of orbital tumors. Additionally, new information on incidence and behavior of tumors resulting from environmental and social trends is included. Written and edited by leaders in the fields of ophthalmology and oncology, Orbital Tumors, 2nd edition builds upon the first edition, proving to be a useful reference for orbital specialists and of significant interest for everyone dealing with orbital pathology from a clinical and scientific point of view.