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Retinal Degeneration
Par Bernhard H.F. Weber, Thomas Langmann. 2013
Over the past decades, knowledge about the cellular and molecular basis underlying the visual process has remarkably increased. In Retinal…
Degeneration: Methods and Protocols, expert researchers in the field provide a guide of relevant and state-of-the-art methods for studying retinal homeostasis and disease. These include methods and techniques for addressing cell culture systems and animal models of disease, their generation, their phenotypic and molecular characterization as well as their use in therapeutic approaches to the retina. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Retinal Degeneration: Methods and Protocols aids scientists in continuing to study the cutting-edge techniques of retinal cell biology in health and disease.The Last Waltz: The Strauss Dynasty and Vienna
Par John Suchet. 2015
Captured in a beautiful package, including more than fifty color photographs, The Last Waltz tells the intriguing story of of…
the Viennese Strauss family known for producing some of the best known, best loved music of the nineteenth century. Johann and Josef Strauss, the Waltz Kings, composed hundreds of instantly recognizable and enduringmelodies, including The Blue Danube Waltz, Tales from the Vienna Woods, Voices of Spring and The Radetzky March. Their iconic music has been featured on the scores of nearly a thousand films.Yet despite their success, this was a family riven with tension, feuds and jealousy, living in a country that was undergoing seismic upheaval. Through the personal and political chaos, the Strauss family continued to compose music to which the Viennese - anxious to forget their troubles - could dance and drank champagne, even as their country hurtled towards oblivion at the hands of the First World War. Classical music expert and radio host John Suchet skillfully portrays this gripping story, capturing the family dramas, the tensions, triumphs and disasters against the turbulent backdrop of Austria in the nineteenth century, from revolution to regicide.All about Your Eyes
Par Jennifer S. Weizer, Sharon Fekrat. 2006
A concise, easy-to-understand reference book, All about Your Eyes tells you what you need to know to care for your…
eyes and what to expect from your eye doctor.In this reliable guide, leading eye care experts:--explain how healthy eyes work--describe various eye diseases, including pink eye, cataract, glaucoma, age-related macular degeneration, and diabetic retinopathy--provide up-to-date information on eye surgery, including refractive, laser, and cosmeticFor each eye problem, the authors describe in simple, straightforward language--what it is--the symptoms--what, if anything, you can do to prevent it--when to call the doctor--the treatment--the likelihood of recoveryAll about Your Eyes includes a glossary of technical terms and, following each entry, links to web sites where further information may be found.Despite a plethora of scientific literature devoted to vision research and the trend toward integrative research the borders between…
disciplines remain a practical difficulty To address this problem this book provides a systematic and comprehensive overview of vision from various perspectives ranging from neuroscience to cognition and from computational principles to engineering developments It is written by leading international researchers in the field with an emphasis on linking multiple disciplines and the impact such synergy can lead to in terms of both scientific breakthroughs and technology innovations It is aimed at active researchers and interested scientists and engineers in related fieldsCataract Blindness and Simulation-Based Training for Cataract Surgeons: An Assessment of the HelpMeSee Approach
Par Jianhui Hu, Peter Glick, James R. Broyles, Yee-Wei Lim. 2012
Cataracts cause about half of all cases of blindness worldwide, largely in developing countries. HelpMeSee Inc. is developing a simulator-based…
method for rapid cataract surgical training that RAND researchers determined could significantly help to close the backlog of cataract cases, expected to be 32 million globally by 2020. For this to occur, challenges in the areas of outreach, quality monitoring, and public acceptance must be met.Porcelain: A Memoir
Par Moby. 2016
From one of the most interesting and iconic musicians of our time, a piercingly tender, funny, and harrowing account of…
the path from suburban poverty and alienation to a life of beauty, squalor, and unlikely success out of the NYC club scene of the late '80s and '90s.There were many reasons Moby was never going to make it as a DJ and musician in the New York club scene. This was the New York of Palladium; of Mars, Limelight, and Twilo; of unchecked, drug-fueled hedonism in pumping clubs where dance music was still largely underground, popular chiefly among working-class African Americans and Latinos. And then there was Moby--not just a poor, skinny white kid from Connecticut, but a devout Christian, a vegan, and a teetotaler. He would learn what it was to be spat on, to live on almost nothing. But it was perhaps the last good time for an artist to live on nothing in New York City: the age of AIDS and crack but also of a defiantly festive cultural underworld. Not without drama, he found his way. But success was not uncomplicated; it led to wretched, if in hindsight sometimes hilarious, excess and proved all too fleeting. And so by the end of the decade, Moby contemplated an end in his career and elsewhere in his life, and put that emotion into what he assumed would be his swan song, his good-bye to all that, the album that would in fact be the beginning of an astonishing new phase: the multimillion-selling Play. At once bighearted and remorseless in its excavation of a lost world, Porcelain is both a chronicle of a city and a time and a deeply intimate exploration of finding one's place during the most gloriously anxious period in life, when you're on your own, betting on yourself, but have no idea how the story ends, and so you live with the honest dread that you're one false step from being thrown out on your face. Moby's voice resonates with honesty, wit, and, above all, an unshakable passion for his music that steered him through some very rough seas. Porcelain is about making it, losing it, loving it, and hating it. It's about finding your people, your place, thinking you've lost them both, and then, somehow, when you think it's over, from a place of well-earned despair, creating a masterpiece. As a portrait of the young artist, Porcelain is a masterpiece in its own right, fit for the short shelf of musicians' memoirs that capture not just a scene but an age, and something timeless about the human condition. Push play.Ocular Transporters in Ophthalmic Diseases and Drug Delivery
Par Colin J. Barnstable, Joyce Tombran-Tink. 2008
In this exceptionally important new work, a panel of distinguished authors discusses all the latest developments in the study of…
ocular transporters. Focusing on the molecular characteristics, localization, and substrate specificities in various compartments of the eye, this volume discusses how transporters regulate the clarity of the cornea and lens, the movements of fluids across the ciliary epithelium and nutrients across the retinal pigment epithelium.The Multi-Talented Mr.Erskine
Par Katherine Elise Chaddock. 2012
This first biography of John Erskine views him in the larger contexts of the mass culture and expanded commercialism that…
helped propel his fame. It also relates a life narrative that demonstrates perils of academic celebrity along a conceptual path from public intellectual to pop icon.Vision Research Protocols
Par P. Elizabeth Rakoczy. 2001
Elizabeth Rakcozy and a team of leading clinical and experimental scientists describe in step-by-step detail the key techniques essential to…
effective molecular biological research in ophthalmology and optometry. These readily reproducible methods are adapted to the special requirements of vision research, with coverage that ranges from the most basic to the most sophisticated technologies. Included are methods for the down-regulation of gene expression, new gene therapy techniques, and for the development of transgenic and knockout animal models for testing novel therapies. Eminently accessible and clinically relevant, Vision Research Protocols provides experimental and biomedical investigators in ophthalmology and optometry with a rich panoply of most powerful tools with which to ask--and answer--all the important questions emerging from the dramatically advancing work in vision research today.Studies on Retinal and Choroidal Disorders
Par Thomas W. Gardner, Robert D. Stratton, William W. Hauswirth. 1984
Studies on Retinal and Choroidal Disorders examines the role that oxidative and nitrosative stress plays in the complex physiology and…
pathophysiology of the retina and choroid. Both the basic science researcher and the clinical practitioner can use this book as a guide to the current understanding of retinal and choroidal cellular mechanisms involved in aging and disease. Beginning with a review of oxidative stress and inflammation in the pathoetiology of AMD and a review of the complement system in the retina, the book then takes a detailed look at oxidative stress in lipid metabolism and oxidized lipoproteins in the retina. It examines the anti-apoptotic activity of α-crystallins in the presence of glutathione, oxidative stress in the mitochondria and endoplasmic reticulum, the role of iron in retinal disease, the mechanisms of pathological VEGF expression, NAPDH oxidase mechanisms, and Hepatocyte Growth Factor in oxidative stress in the retina. A detailed look at the Ccl2-/-/Cx3cr1-/- mouse model of AMD follows. Then a detailed examination of the systemic changes in AMD is followed by a discussion of cerium oxide nanoparticle reduction of oxidative stress. Two chapters discuss progenitor cells in the cause and treatment of retinal diseases including AMD and diabetic retinopathy. Natural compounds in the prevention and treatment of retinal diseases are exhaustively presented, followed by a chapter on serotonin 5-HT1A receptor agonists in oxidative stress of the retina. The current anti-VEGF treatment strategies of neovascular AMD are then given. The volume continues with a detailed look at nitric oxide and inducible nitric oxide synthase in retinal vascular disease, an explanation of an in vivo technique of studying the effect of lipid hydroperoxides on circulating leucocytes in the retina, an excellent review of oxidative stress in retinopathy of prematurity, and a look at VEGF induced oxidative stress in the retinal ganglion cell. The book ends with a detail examination of the role of carotenoids in retinal health and disease. These 31 chapters summarize what is known about oxidative stress in retinal and choroidal disorders. All those involved with degenerative diseases of the eye will find Studies on Retinal and Choroidal Disorders to be illuminating and comprehensive.Visual Dysfunction in Diabetes
Par Colin J. Barnstable, Joyce Tombran-Tink, Thomas W. Gardner. 2012
An exciting contribution to the field, Visual Dysfunction in Diabetes: The Science of Patient Impairment and Improvement is designed with…
two overriding objectives: to help readers understand the impact of vision impairment in people living daily with diabetes rather than considering diabetic retinopathy solely as a medical problem, and to explore what we know and don't know about the ways diabetes affect the eye. With the plethora of new information being generated, there are still a series of fundamental questions that must be addressed if effective treatments for diabetic retinopathy are to be found and applied. Developed by a renowned group of authorities, Visual Dysfunction in Diabetes: The Science of Patient Impairment and Improvement offers responses and context for a range of questions, such as: do metabolic factors beyond glucose contribute to vision-threatening diabetic retinopathy? If so, how do these lead to vision impairment? Is diabetic retinopathy a response to systemic metabolic abnormalities or are there unique ocular problems related to insulin resistance? What is the relationship between the neural, vascular, and inflammatory abnormalities in diabetic retinopathy? Do they represent a pathological cascade induced sequentially or simultaneous responses to one or more metabolic perturbations? The authors note that if we do not address these types of questions, it is possible that the long process of developing new therapeutics will target only one arm of the pathology and leave the retina open to damaging consequences of the others. State-of-the-art, comprehensive, and an invaluable addition the research and clinical literature, Visual Dysfunction in Diabetes: The Science of Patient Impairment and Improvement offers guidance and a significant step toward new scientific approaches that can lessen the devastating vision impairment associated with diabetes.Herpes Simplex Virus Epithelial Keratitis
Par Helena M. Tabery. 2010
This book on Herpes Simplex Virus Epithelial Keratitis shows a kind of 'living histology', revealing both morphological and dynamic features…
of the disease, and explaining mechanisms behind them. It offers great insights helpful for the differential diagnostics and the recognition of less known variants as well as of complications. It is also highly useful for the follow-up of treatment results and the differentiation between an active infection and sequelae. Thus, this book will be an invaluable aid for ophthalmologists and researchers working with ocular surface diseases.The Male Patient in Aesthetic Medicine
Par Berthold Rzany, Mauricio De Maio. 2009
The demand for cosmetic procedures by male patients has increased in recent years. With this trend has come the realization…
that male aesthetic needs are different from female aesthetic needs. This book is the first hands-on guide dedicated exclusively to the aesthetic treatment of the male patient, and provides cosmetic surgeons with important information on how to obtain a natural male look for such patients. It explains facial aesthetics and the aging process in men, as well as the current aesthetic medicine techniques available. It also offers valuable strategies for avoiding and treating undesired results. Written by internationally known experts in the field, this unique guide enables cosmetic surgeons to achieve the best possible treatment outcomes, as well as increased satisfaction in male patients.Vitreous
Par J. Sebag. 2014
The vitreous body long has been the most mysterious of all ocular structures, owing perhaps to its seeming simplicity. There…
have been few concerted, sustained efforts to unravel the mysteries of how vitreous is composed and what role it plays in normal physiology as well as pathology. Over the years, however, many studies have produced important findings concerning vitreous biochemistry, structure, physiology, and pathobiology. Published on the 25th anniversary of Sebag's first book on Vitreous, this second installment is nearly five times longer than its predecessor, reflecting how much has been learned in the past quarter century. This well-constructed compendium not only addresses the most current scientific knowledge, but also reviews clinical perspectives in a manner that lends richness to the scope of the book. Written by 90 authors, this book has 56 chapters organized into 7 sections: Biochemistry; Anatomy, Development, and Aging; Pathology/Pathobiology; Physiology and Phamacotherapy; Posterior Vitreo-Retinal Surgery; Peripheral Vitreo-Retinal Surgery; and Pharmacologic Vitreolysis. With a foreword by Coleman & Lincoff and an introduction by Wallace Foulds, Sebag's latest tome on vitreous is destined to be the authoritative text for years to come.Uveitis
Par George N. Papaliodis. 2017
Uveitis is a practical guide for the diagnosis and treatment of uveitis and ocular inflammatory diseases. This text provides uveitis…
specialists, practicing ophthalmologists, and ophthalmology residents with the appropriate diagnostic testing and evidenced-based therapeutic options for managing patients afflicted with these conditions. The realm of ocular inflammatory diseases is constantly changing with improved diagnostic modalities and treatment options, however, despite these innovations, the ocular inflammatory diseases, including uveitis, are the third leading cause of blindness worldwide. Written and edited by leaders in the fields of ophthalmology, rheumatology, internal medicine, infectious disease, and oncology, Uveitis addresses the latest advances in the field, from the advent of PCR technology, intraocular depot steroid implants, neoplastic and infectious diseases masquerading as uveitis, and the use of systemic immunomoduatory therapies (including biologic agents/humanized monoclonal antibodies in the armamentarium).Adele: The Biography
Par Chas Newkey-Burden. 2011
Adele's soulful voice, catchy hits, and vulnerable personality have won her critical acclaim and widespread popularity. She has topped the…
charts in 18 countries and swept the top awards at the 2012 Grammys—but who is she? How has her tempestuous life that influenced her heartbreaking tracks? How did she overcome the challenges that threatened to derail her career? In Adele, veteran celebrity biographer Chas Newkey-Burden traces her story from her childhood in London, where she began singing at the age of four. During her teenage years she wrote her own music and attended the BRIT school, alongside the likes of Leona Lewis. After posting demos on her MySpace webpage, she earned a record deal and quickly captured hearts. Adele remains an unlikely icon. Her looks are unusual in a formulaic world of celebrity image, she suffers badly with pre-stage nerves, and she once canceled a crucial promotional trip to the U.S. because she felt too down to travel. This is a full, unflinching portrait of a genuine talent and inspiring, uncompromising woman—the curvy girl next door who conquered the world.New Music at Darmstadt
Par Martin Iddon. 2013
New Music at Darmstadt explores the rise and fall of the so-called 'Darmstadt School', through a wealth of primary sources…
and analytical commentary. Martin Iddon's book examines the creation of the Darmstadt New Music Courses and the slow development and subsequent collapse of the idea of the Darmstadt School, showing how participants in the West German new music scene, including Herbert Eimert and a range of journalistic commentators, created an image of a coherent entity, despite the very diverse range of compositional practices on display at the courses. The book also explores the collapse of the seeming collegiality of the Darmstadt composers, which crystallised around the arrival there in 1958 of the most famous, and notorious, of all post-war composers, John Cage, an event Carl Dahlhaus opined 'swept across the European avant-garde like a natural disaster'.African Rhythms: The Autobiography of Randy Weston
Par Randy Weston. 1967
The pianist, composer, and bandleader Randy Weston is one of the world's most influential jazz musicians and a remarkable storyteller…
whose career has spanned five continents and more than six decades. Packed with fascinating anecdotes, African Rhythms is Weston's life story, as told by him to the music journalist Willard Jenkins. It encompasses Weston's childhood in Brooklyn's Bedford-Stuyvesant neighborhood--where his parents and other members of their generation imbued him with pride in his African heritage--and his introduction to jazz and early years as a musician in the artistic ferment of mid-twentieth-century New York. His music has taken him around the world: he has performed in eighteen African countries, in Buddhist temples and Shinto shrines, in the Canterbury Cathedral, and at the grand opening of the Bibliotheca Alexandrina: The New Library of Alexandria. Africa is at the core of Weston's music and spirituality. He has traversed the continent on a continuous quest to learn about its musical traditions, produced its first major jazz festival, and lived for years in Morocco, where he opened a popular jazz club, the African Rhythms Club, in Tangier. Weston's narrative is replete with tales of the people he has met and befriended, and with whom he has worked. He describes his unique partnerships with Langston Hughes, the musician and arranger Melba Liston, and the jazz scholar Marshall Stearns, as well as his friendships and collaborations with Duke Ellington, Dizzy Gillespie, Coleman Hawkins, Thelonious Monk, Billy Strayhorn, Max Roach, Charlie Parker, Miles Davis, the novelist Paul Bowles, the Cuban percussionist Candido Camero, the Ghanaian jazz artist Kofi Ghanaba, the Gnawa musicians of Morocco, and many others. With African Rhythms, an international jazz virtuoso continues to create cultural history.Stefan Wolpe and the Avant-Garde Diaspora
Par Brigid Cohen. 2012
The German-Jewish emigre composer Stefan Wolpe was a vital figure in the history of modernism, with affiliations ranging from the…
Bauhaus, Berlin agitprop and the kibbutz movement to bebop, Abstract Expressionism and Black Mountain College. This is the first full-length study of this often overlooked composer, launched from the standpoint of the mass migrations that have defined recent times. Drawing on over 2000 pages of unpublished documents, Cohen explores how avant-garde communities across three continents adapted to situations of extreme cultural and physical dislocation. A conjurer of unexpected cultural connections, Wolpe serves as an entry-point to the utopian art worlds of Weimar-era Germany, pacifist movements in 1930s Palestine and vibrant art and music scenes in early Cold War America. The book takes advantage of Wolpe's role as a mediator, bringing together perspectives from music scholarship, art history, comparative literature, postcolonial studies and recent theories of cosmopolitanism and diaspora.Small-Gauge Vitrectomy for Diabetic Retinopathy
Par Ulrich Spandau, Zoran Tomic. 2015
This book describes step by step how to operate on the patient with diabetic retinopathy. After thorough explanation of surgical…
planning, including the potential need to perform individual procedures at different time points, each stage of the vitrectomy is clearly documented with the aid of color photographs and drawings as well as online surgical videos. Variations in approach are described that are potentially of value, depending on whether one is dealing with a straightforward diabetic retinopathy or a difficult case of tractional retinal detachment. In the second part of the book, a series of case reports are presented that illustrate the surgical procedures applicable in different circumstances. In addition, pearls and pitfalls are highlighted. Small-Gauge Vitrectomy for Diabetic Retinopathy will be an ideal source of information and guidance for all who are embarking upon such surgery or wish to further hone their skills.