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The Road Years: A Memoir, Continued . . .
Par Rick Mercer. 2023
THE INSTANT #1 BESTSELLERRick Mercer is back—again!—with the eagerly awaited sequel to his bestselling memoirAt the end of his memoir…
Talking to Canadians, Rick Mercer was poised to make the biggest leap yet in his extraordinary career. Having overcome a serious lack of promise as a schoolboy and risen through the showbiz ranks—as an aspiring actor, star of a surprisingly successful one-man show about the Meech Lake Accord, co-founder of This Hour Has 22 Minutes, creator and star of the dark-comedy sitcom Made in Canada—he was about to tackle his biggest opportunity yet. The Road Years picks up the story at that exciting point, with the greenlighting of what would become Rick Mercer Report. Plans for the show, of course, included political satire and Rick’s patented rants. But Rick and his partner, Gerald Lunz, were also determined to do something that comedy tends to avoid as too challenging: they would emphasize the positive. Rick would travel from coast to coast to coast in search of everything that’s best about Canada, especially its people. He found a lot to celebrate, naturally, and was rewarded with a huge audience and a run of 15 seasons. The Road Years tells the inside story of that stupendous success. A time when Rick was heading to another town—or military base, sports centre, national park—to try dogsledding, chainsaw carving, and bear tagging; hang from a harness (a lot); ride the “Train of Death;” plus countless other joyous and/or reckless assignments. Added to the mix were encounters with the country’s great. Every living prime minister. Rock and roll royalty from Rush to Randy Bachman. Olympians and Paralympians. A skinny-dipping Bob Rae. And Jann Arden, of course, who gets a chapter to herself. Along the way he even found the time to visit several countries in Africa and co-found and champion the charity Spread the Net, which has gone on to protect the lives of millions. Join the celebration, and revive a wealth of happy memories, with what is Rick Mercer’s funniest, most fascinating book yet.Pride and Persistence: Stories of Queer Activism (Do You Know My Name? #4)
Par Mary Fairhurst Breen. 2023
The activists between these pages have stood up for the queer community, whether on their own behalf or in support…
of people they love. Some made a difference by confronting injustice; others dared to be fully themselves.Donor-Acceptor Cyclopropanes in Organic Synthesis
Par Prabal Banerjee, Akkattu T. Biju. 2024
Donor-Acceptor Cyclopropanes in Organic Synthesis Facilitate milder, simpler reactions in organic synthesis with this cutting-edge family of building blocks Donor-Accepted…
Cyclopropanes, or DACs, have attracted a resurgence of interest from organic chemists in recent decades for their role in facilitating various reactions such as cycloadditions, annulations, ring-opening and enantioselective transformations. The structural arrangement of DACs leads to milder, simpler reaction conditions, which have made them indispensable for a range of fundamentally and industrially important processes. Donor-Acceptor Cyclopropanes in Organic Synthesis covers comprehensively the chemistry and applications of this compound class. The result is an invaluable guide for any researcher looking to bring DACs to bear in their own areas of research or development. Readers will also find: A brief introduction of the history and reactivity of DACs Detailed discussion of reactions including Lewis acid-catalyzed cycloadditions, metal-free activation, asymmetric transformations, organocatalysis, and many more Application of DACs in natural product synthesis and pharmaceutical/agrochemical research Donor-Acceptor Cyclopropanes in Organic Synthesis is ideal for organic chemists, experts in catalysis, pharmaceutical researchers, and any other scientists interested in facilitating milder, simpler reactions.Der Bauphysik-Kalender 2024 gibt Praxishinweise für die klimagerechte Planung von Gebäuden, aber auch von urbanen Räumen. Diese sind durch die…
hohen Verdichtungen und Versiegelungen besonders anfällig gegenüber der Klimaveränderung mit häufigeren Extremwetterereignissen. Aber sie sind gestaltbare Orte, an denen durch eine interdisziplinäre und zukunftsorientierte Planung eine weitere Verschärfung des Klimawandels gebremst und die Resilienz von Mensch, Flora und Fauna gegenüber seinen Folgen gestärkt werden kann. Das Buch bietet aktuelles Wissen um bauphysikalische Prozesse zu verstehen, Potenziale von Konstruktionen gezielt auszuschöpfen und die Gebäudetechnik und Automatisierung funktional zu halten. Außerdem werden Tools und Nachweisverfahren getestet und kommentiert, mit deren Hilfe Bilanzen über die Umweltwirkungen von Gebäuden bzw. Bewertungen der Klimaanpassung von Gebäuden ermittelt werden können. Der zweite diesjährige Schwerpunkt Brandschutz widmet sich der Holzbauweise sowie der Untersuchung von Brandeinwirkungen durch E-Fahrzeuge und kraftstoffbetriebene Fahrzeuge in Parkgaragen. Der Bauphysik-Kalender 2024 bietet eine solide Arbeitsgrundlage und ein verlässliches aktuelles Nachschlagewerk für die Planung in Neubau und Bestand, alle Kapitel bewegen sich nahe an der Ingenieurpraxis. Das Buch enthält Planungshinweise, Konzepte und Praxisbeispiele.Peptide Self-Assembly and Engineering: Fundamentals, Structures, and Applications
Par Xuehai Yan. 2024
Peptide Self-Assembly and Engineering State-of-the-art research in peptide self-assembly, with coverage of fundamental aspects of how peptides self-assemble and an…
extensive number of applications Peptide Self-Assembly and Engineering: Fundamentals, Structures, and Applications (2V set) covers the latest progresses in the field of peptide self-assembly and engineering, including the fundamental principles of peptide self-assembly, new theory of nucleation and growth, thermodynamics and kinetics, materials design rules, and precisely controlled structures and unique functions. The broad contents from this book enable readers to obtain a systematical and comprehensive knowledge in the field of peptide self-assembly and engineering. Contributed by the leading scientists and edited by a highly qualified academic and an authority in the field, Peptide Self-Assembly and Engineering includes information on: Emerging areas in peptide assembly, such as immune agents, bioelectronics, energy conversion, flexible sensors, biomimetic catalysis, and more Existing applications in biomedical engineering, nanotechnology, and photoelectronics, including tissue engineering, drug delivery, and biosensing devices History of peptide self-assembly for design of functional materials and peptides’ unique mechanical, optical, electronic, and biological properties Various solvent conditions, such as pH, ionic strength, and polarity, that can affect the structure and stability of peptide assemblies A very comprehensive reference covering the latest progresses in the field of peptide self-assembly and engineering, Peptide Self-Assembly and Engineering is an essential resource for all scientists performing research intersecting with the subject, including biochemists, biotechnologists, pharmaceutical chemists, protein chemists, materials scientists, and medicinal chemists.Drug Development for Gene Therapy: Translational Biomarkers, Bioanalysis, and Companion Diagnostics
Par Yanmei Lu, Boris Gorovits. 2024
Drug Development for Gene Therapy Industry-centric perspective on translational and bioanalytical challenges and best practices for gene therapies Drug Development…
for Gene Therapy focuses on the translational and bioanalytical challenges and best practices for gene therapy modalities, presenting a significant body of data, including information related to safety and efficacy, necessary to advance through the development pipeline into clinical use. The text covers bioanalytical methods and platforms including patient screening assays, different PCR tests, enzyme activity assays, ELISpot, NGS, LC/MS, and immunoassays, with FDA and EMA guidelines on gene therapy safety and efficacy, along with companion diagnostics regulations from US and EU perspectives. The chapters offer an in-depth discussion of the basics and best practices for translational biomarkers, bioanalysis, and developing companion diagnostics / lab tests for gene therapies in the pharma and biopharma industries. To aid in reader comprehension, the text includes clinical examples of relevant therapies in related chapters. Some of the core topics covered include study design, immunogenicity, various bioanalytical methods and their applications, and global regulatory issues. Written by two highly qualified authors with significant experience in the field, Drug Development for Gene Therapy includes information on: Bioanalytical methods to detect pre-existing antibodies against adeno-associated viruses (AAV) capsids Detection of cellular immunity and humoral response to viral capsids and transgene proteins, and immunogenicity of gene therapy products Nonclinical and clinical study considerations and methods for biodistribution and shedding Quantification of transgene protein expression and biochemical function, and substrate and distal pharmacodynamic biomarker measurements for gene therapy Detection and quantification of rAAV integration and off-target editing Current regulatory landscape for gene therapy product development and the role of biomarkers and general regulatory considerations for gene therapy companion diagnostics With comprehensive coverage of the subject, Drug Development for Gene Therapy is a must-have resource for researchers and developers in the areas of pharmaceuticals, biopharmaceuticals, and contract research organizations (CROs), along with professors, researchers, and advanced students in chemistry, biological, biomedical engineering, pharmaceuticals, and medical sciences.Epigenetics and Health: A Practical Guide
Par Michelle McCulley. 2024
Epigenetics and Health An incisive and contemporary discussion of epigenetic phenomena applied to human health and disease Epigenetics and Health:…
A Practical Guide delivers a thorough and insightful exploration of the basic principles of gene function, gene regulation, and gene expression. The author explains how epigenetic modifications alter gene expression and demonstrate the role played by environmental factors—including nutrition, exercise, toxins, and stress—in gene regulation, as well as their potential health consequences. The book presents current methods for analyzing epigenetic variation, including NGS applications and bioinformatic analysis. Readers will be encouraged to question, analyze, and critically appraise the literature on epigenetics to further develop their understanding. They’ll also find: Explorations of epigenetic mechanisms, homeostasis, and the potential for manipulating the epigenome Practical discussions of methods for epigenetic analyses How to address cancer epigenetics, mental health epigenetics, and guidance on developing an epigenetics research project Epigenetics and Health: A Practical Guide will benefit practicing geneticists and medical geneticists seeking insights into epigenetic phenomena applied to human health and disease.Proceedings of the 10th Hydrogen Technology Convention, Volume 3: WHTC 2023, 22-26 May, Foshan, China (Springer Proceedings in Physics #395)
Par Hexu Sun, Wei Pei, Yan Dong, Hongmei Yu, Shi You. 2024
These proceedings highlight the latest advances in fundamental research, technologies and applications of hydrogen energy and fuel cells. In recent…
years, energy conversion between electricity and hydrogen energy has attracted increasing attention as a way to adjust the load of the grid. These conference records discuss and exchange cutting-edge findings and technological developments in fields such as new proton exchange membrane electrolysers, new electrode materials and catalysts, renewable energy, off-grid/grid-connected water electrolysis for hydrogen production, key materials and components of fuel cells, high-temperature solid oxide water electrolysis, energy storage technologies and research, CO2 hydrogenation to methanol, nitrogen to ammonia and other applications with industrial potential.The main topics of the proceedings include:1) Policies and strategies for hydrogen energy and fuel cells;2) Advanced proton exchange membranes, electrodes and catalyst materials for water electrolysis;3) Advanced hydrogen compression, storage, transportation and distribution technologies;4) Safety and related standards;5) Manufacture and R&D of key materials and components of fuel cells and stack systems.This book unveils the most advanced techniques and innovative applications in the natural language processing (NLP) field. It uncovers the…
secrets to enhancing language understanding, and presents practical solutions to different NLP tasks, as text augmentation, paraphrase generation, and restoring spaces and punctuation in multiple languages. It unlocks the potential of hierarchical multi-task learning for cross-lingual phoneme recognition, and allows readers to explore more real-world applications such as error correction, aggregating industrial security findings as well as predicting music emotion values from social media conversations. "Practical Solutions for Diverse Real-World NLP Applications" is the suitable guidebook for researchers, students, and practitioners as it paves the way for them by delivering invaluable insights and knowledge.AQA GCSE (9-1) Combined Science Trilogy Student Book 2
Par Nick Dixon, Nick England, Richard Grime, Nora Henry, Ali Hodgson, Steve Witney. 2016
Exam Board: AQALevel: GCSESubject: ScienceFirst Teaching: September 2016First Exam: June 2018AQA approved.Build your students' scientific thinking, analysis and evaluation with…
this textbook that leads them seamlessly from basic concepts to more complicated theories, with topical examples, practical activities and mathematical support throughout.Developed specifically for the 2016 AQA GCSE Combined Science Trilogy specification.-Builds experimental, analytical and evaluation skills with activities that introduce the 16 required practicals, along with extra Working Scientifically tasks for broader learning-Provides plenty of opportunity for students to apply their knowledge and understanding with Test Yourself questions, Show You Can challenges, Chapter review questions and synoptic practice questions-Supports Foundation and Higher tier students in one book, with Higher tier-only content clearly marked.Book 2 covers the topics in Biology Paper 2, Chemistry Paper 2 and Physics Paper 2FREE GCSE SCIENCE TEACHER GUIDESThese will be provided for free via our website. Biology will be available in OctoberChemistry will be available in JanuaryPhysics will be available in MarchTo request your free copies please email science@hodder.co.ukOptimising NMR Spectroscopy Through Method and Software Development (Springer Theses)
Par Jonathan Yong. 2024
This book provides a comprehensive overview of Nuclear Magnetic Resonance (NMR) theory, its applications, and advanced techniques to improve the…
quality and speed of NMR data acquisition. In this book, the author expands his outstanding Ph.D. thesis and provides a valuable resource for researchers, professionals, and students in the field of NMR spectroscopy. The book covers quantum mechanics basics, and topics like density operators, pulse sequences, 1D pulse acquisition, INEPT (Insensitive nuclei enhancement by polarization transfer), product operators, and 2D NMR principles. It also explores innovative experiments like States HSQC (Heteronuclear Single Quantum Coherence) and echo-antiecho HSQC with gradients. In the subsequent chapters, the author discusses Pure Shift NMR, including PSYCHE (Pure Shift Yielded by Chirp Excitation) and its optimizations, such as waveform parameterization and time-reversal methods. The 'Discrete PSYCHE' approach and Ultrafast PSYCHE-iDOSY (Diffusion-ordered spectroscopy) are also highlighted. This book presents the POISE (Parameter Optimisation by Iterative Spectral Evaluation) software for real-time NMR experiment optimization, including pulse width calibration and Ernst angle optimization, and demonstrates applications across various NMR experiments. Lastly, the book examines accelerated 2D NMR data collection and the NOAH (NMR by Ordered Acquisition using 1H detection) supersequences, emphasizing automated pulse program creation using GENESIS (GENEration of Supersequences In Silico). Covered NMR experiments include 13C sensitivity-enhanced HSQC, 15N HMQC (Heteronuclear Multiple Quantum Coherence), dual HSQC, HSQC-TOCSY (Total Correlation Spectroscopy), HMBC (Heteronuclear Multiple Bond Correlation), and ADEQUATE (Adequate Sensitivity Double-Quantum Spectroscopy).Genomics Data Analysis for Crop Improvement (Springer Protocols Handbooks)
Par Priyanka Anjoy, Kuldeep Kumar, Girish Chandra, Kishor Gaikwad. 2024
This book addresses complex problems associated with crop improvement programs, using a wide range of programming solutions, for genomics data…
handling and sustainable agriculture. It describes important concepts in genomics data analysis and sequence-based mapping approaches along with references. The book contains 16 chapters on recent developments in several methods of genomic data analysis for crop improvements and sustainable agriculture, all authored by eminent researchers who are experts in their fields. These chapters focus on applications of a wide range of key bioinformatics topics, including assembly, annotation, and visualization of next-generation sequencing (NGS) data; expression profiles of coding and noncoding RNA; statistical and quantitative genetics; trait-based association analysis, quantitative trait loci (QTL) mapping, and artificial intelligence in genomic studies. Real examples and case studies in the book will come in handy when applying the techniques. The relative scarcity of reference materials covering bioinformatics applications as compared with the readily available books also enhances the utility of this book. The targeted readers of the book are scientists, researchers, and bioinformaticians from genomics and advanced breeding in different areas. The book will appeal to the applied researchers engaged in crop improvements and sustainable agriculture by using bioinformatics tools, students, research project leaders, and practitioners from the various marginal disciplines and interdisciplinary research.Progress in Landslide Research and Technology, Volume 2 Issue 1, 2023 (Progress in Landslide Research and Technology)
Par Irasema Alcántara-Ayala, Željko Arbanas, Sabatino Cuomo, David Huntley, Kazuo Konagai, Snježana Mihalić Arbanas, Matjaž Mikoš, Kyoji Sassa, Shinji Sassa, Huiming Tang, Binod Tiwari. 2023
This open access book provides an overview of the progress in landslide research and technology and is part of a book…
series of the International Consortium on Landslides (ICL). The book provides a common platform for the publication of recent progress in landslide research and technology for practical applications and the benefit for the society contributing to the Kyoto Landslide Commitment 2020, which is expected to continue up to 2030 and even beyond to globally promote the understanding and reduction of landslide disaster risk, as well as to address the 2030 Agenda Sustainable Development Goals.Single Cell Analysis: Methods and Protocols (Methods in Molecular Biology #2752)
Par Miodrag Gužvić. 2024
This volume explores the latest advancements and techniques used to study cell analysis, their capabilities, and the type of results…
that can be obtained. The chapters in this book cover topics such as FACS; fluorescence microscopy; organic spectroscopy such as MALDI; inorganic spectroscopy such as ICP-MS; and sequencing. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and practical, Single Cell Analysis: Methods and Protocols is a valuable tool for any researcher interested in learning more about this important and developing field.Handbook of Digital Face Manipulation and Detection: From DeepFakes to Morphing Attacks (Advances in Computer Vision and Pattern Recognition)
Par Christian Rathgeb, Ruben Tolosana, Ruben Vera-Rodriguez, Christoph Busch. 2022
This open access book provides the first comprehensive collection of studies dealing with the hot topic of digital face manipulation such as DeepFakes,…
Face Morphing, or Reenactment. It combines the research fields of biometrics and media forensics including contributions from academia and industry. Appealing to a broad readership, introductory chapters provide a comprehensive overview of the topic, which address readers wishing to gain a brief overview of the state-of-the-art. Subsequent chapters, which delve deeper into various research challenges, are oriented towards advanced readers. Moreover, the book provides a good starting point for young researchers as well as a reference guide pointing at further literature. Hence, the primary readership is academic institutions and industry currently involved in digital face manipulation and detection. The book could easily be used as a recommended text for courses in image processing, machine learning, media forensics, biometrics, and the general security area.Plant Resistance to Insects in Major Field Crops
Par Sarwan Kumar, Michael Furlong. 2024
This edited book is a comprehensive collection of information on host plant resistance to insects in major field crops. The…
focus of the book is to make the audience aware of the latest developments in host plant resistance in major field crops and how it can be used for sustainable pest management solutions. It deals with the insect-plant interactions, plant defence responses to herbivore attacks, plant phenotyping, and breeding for insect resistance. Insects are an important group of biotic stresses that limit crop productivity in many regions of the world. At present, they are largely managed by synthetic insecticides which have their own adverse effects including insecticide resistance, pest resurgence, environmental pollution, and pesticide residues, to name a few. Thus, there is an urgent need to develop alternate pest management strategies that can provide a sustainable solution to pest problems. Host plant resistance is considered an important pest management strategy as it offers an effective, economical, and environmental friendly solution to pest problems. This book is of interest to postgraduate students, crop entomologists, and breeders working on host plant resistance to insect pests. It is also valuable for teachers, researchers, and climate change scientists.The book serves as an additional reading material for undergraduate and graduate students of agriculture, ecology, and environmental sciences. Agricultural experts from around the world, as well as policymakers, will also find this book helpful.Fundamental and Applied Scientific Research in the Development of Agriculture in the Far East: Agricultural Cyber-Physical Systems, Volume 1 (Lecture Notes in Networks and Systems #733)
Par Khasanov Sayidjakhon Zokirjon ugli, Aleksei Muratov, Svetlana Ignateva. 2024
The scope of this book is cyber-physical systems used for the sustainable development and productivity of the agricultural sector. The…
book contains proceedings of the conference “Fundamental and Applied Scientific Research in the Development of Agriculture in the Far East” (AFE-2022, Tashkent, Uzbekistan). The results of research in the following areas are presented here: software-as-a-service solutions for orchard management, ICT components of Smart Agriculture (SA), farm management platforms, yield monitoring and estimation, IoTs in farming, water management, and smart agriculture machines. The book contains information on the latest technologies in precision agriculture, including real-time technology and big data analytics, fertilizer and sprayer controllers, robotics, variable rate irrigation, networks and remote sensing technologies, etc. The research results presented in the book help in making the right decisions about the allocation of resources in agricultural systems.Conservation of Architectural Heritage: Developing Sustainable Practices (Advances in Science, Technology & Innovation)
Par Maria Luisa Germanà, Natsuko Akagawa, Antonella Versaci, Nicola Cavalagli. 2024
This book presents practical, applicable solutions that contribute to built heritage conservation, discussing challenges like resource constraints, ineffective legislation, lack…
of coordination between different relevant bodies, and absence of public awareness and involvement. This is to maintain the beauty and cultural meaning of the architectural heritage since they are like a glimpse from the past life, representing how people lived, their religions, and beliefs in addition to the primitive but inspirational technology used in construction. As a result, this book is of significant importance to professionals in the fields of architecture, sustainability, as well as policymakers.Geographies of Food: Global Visions of Healthy and Unhealthy Food (Springer Geography)
Par Harrison Esam Awuh, Samuel Agyekum. 2024
The book offers a multi-scale, epistemically diverse, and sense-making perspectives on the food system. The book argues that sustainable food…
system transformation is a complex proposition that can better thrive upon the inclusion of consumer perspectives. The book brings together scholarly works of critical scholars and practitioners who bring to bear the uniqueness of places, cultures, histories and interactions in the milieu of food.Segmentation of the Aorta. Towards the Automatic Segmentation, Modeling, and Meshing of the Aortic Vessel Tree from Multicenter Acquisition: First Challenge, SEG.A. 2023, Held in Conjunction with MICCAI 2023, Vancouver, BC, Canada, October 8, 2023, Procee
Par Antonio Pepe, Gian Marco Melito, Jan Egger. 2024
This book constitutes the First Segmentation of the Aorta Challenge, SEG.A. 2023, which was held in conjunction with the 26th…
International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2023, on October 8, 2023. The 8 full and 3 short papers presented have been carefully reviewed and selected for inclusion in the book. They focus specifically on robustness, visual quality and meshing of automatically generated segmentations of aortic vessel trees from CT imaging. The challenge was organized as a ”container submission” challenge, where participants had to upload their algorithms to Grand Challenge in the form of Docker containers. Three tasks were created for SEG.A. 2023.