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The Road Years: A Memoir, Continued . . .
Par Rick Mercer. 2023
THE INSTANT #1 BESTSELLERRick Mercer is back—again!—with the eagerly awaited sequel to his bestselling memoirAt the end of his memoir…
Talking to Canadians, Rick Mercer was poised to make the biggest leap yet in his extraordinary career. Having overcome a serious lack of promise as a schoolboy and risen through the showbiz ranks—as an aspiring actor, star of a surprisingly successful one-man show about the Meech Lake Accord, co-founder of This Hour Has 22 Minutes, creator and star of the dark-comedy sitcom Made in Canada—he was about to tackle his biggest opportunity yet. The Road Years picks up the story at that exciting point, with the greenlighting of what would become Rick Mercer Report. Plans for the show, of course, included political satire and Rick’s patented rants. But Rick and his partner, Gerald Lunz, were also determined to do something that comedy tends to avoid as too challenging: they would emphasize the positive. Rick would travel from coast to coast to coast in search of everything that’s best about Canada, especially its people. He found a lot to celebrate, naturally, and was rewarded with a huge audience and a run of 15 seasons. The Road Years tells the inside story of that stupendous success. A time when Rick was heading to another town—or military base, sports centre, national park—to try dogsledding, chainsaw carving, and bear tagging; hang from a harness (a lot); ride the “Train of Death;” plus countless other joyous and/or reckless assignments. Added to the mix were encounters with the country’s great. Every living prime minister. Rock and roll royalty from Rush to Randy Bachman. Olympians and Paralympians. A skinny-dipping Bob Rae. And Jann Arden, of course, who gets a chapter to herself. Along the way he even found the time to visit several countries in Africa and co-found and champion the charity Spread the Net, which has gone on to protect the lives of millions. Join the celebration, and revive a wealth of happy memories, with what is Rick Mercer’s funniest, most fascinating book yet.Pride and Persistence: Stories of Queer Activism (Do You Know My Name? #4)
Par Mary Fairhurst Breen. 2023
The activists between these pages have stood up for the queer community, whether on their own behalf or in support…
of people they love. Some made a difference by confronting injustice; others dared to be fully themselves.Donor-Acceptor Cyclopropanes in Organic Synthesis
Par Prabal Banerjee, Akkattu T. Biju. 2024
Donor-Acceptor Cyclopropanes in Organic Synthesis Facilitate milder, simpler reactions in organic synthesis with this cutting-edge family of building blocks Donor-Accepted…
Cyclopropanes, or DACs, have attracted a resurgence of interest from organic chemists in recent decades for their role in facilitating various reactions such as cycloadditions, annulations, ring-opening and enantioselective transformations. The structural arrangement of DACs leads to milder, simpler reaction conditions, which have made them indispensable for a range of fundamentally and industrially important processes. Donor-Acceptor Cyclopropanes in Organic Synthesis covers comprehensively the chemistry and applications of this compound class. The result is an invaluable guide for any researcher looking to bring DACs to bear in their own areas of research or development. Readers will also find: A brief introduction of the history and reactivity of DACs Detailed discussion of reactions including Lewis acid-catalyzed cycloadditions, metal-free activation, asymmetric transformations, organocatalysis, and many more Application of DACs in natural product synthesis and pharmaceutical/agrochemical research Donor-Acceptor Cyclopropanes in Organic Synthesis is ideal for organic chemists, experts in catalysis, pharmaceutical researchers, and any other scientists interested in facilitating milder, simpler reactions.Der Bauphysik-Kalender 2024 gibt Praxishinweise für die klimagerechte Planung von Gebäuden, aber auch von urbanen Räumen. Diese sind durch die…
hohen Verdichtungen und Versiegelungen besonders anfällig gegenüber der Klimaveränderung mit häufigeren Extremwetterereignissen. Aber sie sind gestaltbare Orte, an denen durch eine interdisziplinäre und zukunftsorientierte Planung eine weitere Verschärfung des Klimawandels gebremst und die Resilienz von Mensch, Flora und Fauna gegenüber seinen Folgen gestärkt werden kann. Das Buch bietet aktuelles Wissen um bauphysikalische Prozesse zu verstehen, Potenziale von Konstruktionen gezielt auszuschöpfen und die Gebäudetechnik und Automatisierung funktional zu halten. Außerdem werden Tools und Nachweisverfahren getestet und kommentiert, mit deren Hilfe Bilanzen über die Umweltwirkungen von Gebäuden bzw. Bewertungen der Klimaanpassung von Gebäuden ermittelt werden können. Der zweite diesjährige Schwerpunkt Brandschutz widmet sich der Holzbauweise sowie der Untersuchung von Brandeinwirkungen durch E-Fahrzeuge und kraftstoffbetriebene Fahrzeuge in Parkgaragen. Der Bauphysik-Kalender 2024 bietet eine solide Arbeitsgrundlage und ein verlässliches aktuelles Nachschlagewerk für die Planung in Neubau und Bestand, alle Kapitel bewegen sich nahe an der Ingenieurpraxis. Das Buch enthält Planungshinweise, Konzepte und Praxisbeispiele.Peptide Self-Assembly and Engineering: Fundamentals, Structures, and Applications
Par Xuehai Yan. 2024
Peptide Self-Assembly and Engineering State-of-the-art research in peptide self-assembly, with coverage of fundamental aspects of how peptides self-assemble and an…
extensive number of applications Peptide Self-Assembly and Engineering: Fundamentals, Structures, and Applications (2V set) covers the latest progresses in the field of peptide self-assembly and engineering, including the fundamental principles of peptide self-assembly, new theory of nucleation and growth, thermodynamics and kinetics, materials design rules, and precisely controlled structures and unique functions. The broad contents from this book enable readers to obtain a systematical and comprehensive knowledge in the field of peptide self-assembly and engineering. Contributed by the leading scientists and edited by a highly qualified academic and an authority in the field, Peptide Self-Assembly and Engineering includes information on: Emerging areas in peptide assembly, such as immune agents, bioelectronics, energy conversion, flexible sensors, biomimetic catalysis, and more Existing applications in biomedical engineering, nanotechnology, and photoelectronics, including tissue engineering, drug delivery, and biosensing devices History of peptide self-assembly for design of functional materials and peptides’ unique mechanical, optical, electronic, and biological properties Various solvent conditions, such as pH, ionic strength, and polarity, that can affect the structure and stability of peptide assemblies A very comprehensive reference covering the latest progresses in the field of peptide self-assembly and engineering, Peptide Self-Assembly and Engineering is an essential resource for all scientists performing research intersecting with the subject, including biochemists, biotechnologists, pharmaceutical chemists, protein chemists, materials scientists, and medicinal chemists.Drug Development for Gene Therapy: Translational Biomarkers, Bioanalysis, and Companion Diagnostics
Par Yanmei Lu, Boris Gorovits. 2024
Drug Development for Gene Therapy Industry-centric perspective on translational and bioanalytical challenges and best practices for gene therapies Drug Development…
for Gene Therapy focuses on the translational and bioanalytical challenges and best practices for gene therapy modalities, presenting a significant body of data, including information related to safety and efficacy, necessary to advance through the development pipeline into clinical use. The text covers bioanalytical methods and platforms including patient screening assays, different PCR tests, enzyme activity assays, ELISpot, NGS, LC/MS, and immunoassays, with FDA and EMA guidelines on gene therapy safety and efficacy, along with companion diagnostics regulations from US and EU perspectives. The chapters offer an in-depth discussion of the basics and best practices for translational biomarkers, bioanalysis, and developing companion diagnostics / lab tests for gene therapies in the pharma and biopharma industries. To aid in reader comprehension, the text includes clinical examples of relevant therapies in related chapters. Some of the core topics covered include study design, immunogenicity, various bioanalytical methods and their applications, and global regulatory issues. Written by two highly qualified authors with significant experience in the field, Drug Development for Gene Therapy includes information on: Bioanalytical methods to detect pre-existing antibodies against adeno-associated viruses (AAV) capsids Detection of cellular immunity and humoral response to viral capsids and transgene proteins, and immunogenicity of gene therapy products Nonclinical and clinical study considerations and methods for biodistribution and shedding Quantification of transgene protein expression and biochemical function, and substrate and distal pharmacodynamic biomarker measurements for gene therapy Detection and quantification of rAAV integration and off-target editing Current regulatory landscape for gene therapy product development and the role of biomarkers and general regulatory considerations for gene therapy companion diagnostics With comprehensive coverage of the subject, Drug Development for Gene Therapy is a must-have resource for researchers and developers in the areas of pharmaceuticals, biopharmaceuticals, and contract research organizations (CROs), along with professors, researchers, and advanced students in chemistry, biological, biomedical engineering, pharmaceuticals, and medical sciences.Epigenetics and Health: A Practical Guide
Par Michelle McCulley. 2024
Epigenetics and Health An incisive and contemporary discussion of epigenetic phenomena applied to human health and disease Epigenetics and Health:…
A Practical Guide delivers a thorough and insightful exploration of the basic principles of gene function, gene regulation, and gene expression. The author explains how epigenetic modifications alter gene expression and demonstrate the role played by environmental factors—including nutrition, exercise, toxins, and stress—in gene regulation, as well as their potential health consequences. The book presents current methods for analyzing epigenetic variation, including NGS applications and bioinformatic analysis. Readers will be encouraged to question, analyze, and critically appraise the literature on epigenetics to further develop their understanding. They’ll also find: Explorations of epigenetic mechanisms, homeostasis, and the potential for manipulating the epigenome Practical discussions of methods for epigenetic analyses How to address cancer epigenetics, mental health epigenetics, and guidance on developing an epigenetics research project Epigenetics and Health: A Practical Guide will benefit practicing geneticists and medical geneticists seeking insights into epigenetic phenomena applied to human health and disease.Transactions on Intelligent Welding Manufacturing: Volume V No. 1 2021 (Transactions on Intelligent Welding Manufacturing)
Par Shanben Chen, Yuming Zhang, Zhili Feng. 2024
The primary aim of this book is to provide researchers and engineers from both academic and industry with up-to-date coverage…
of new results in the field of robotic welding, intelligent systems and automation. The book is mainly based on papers selected from the 2022 International Conference on Robotic Welding, Intelligence and Automation (RWIA’2022) in Shanghai and Lanzhou, China. The articles show that the intelligentized welding manufacturing (IWM) is becoming an inevitable trend with the intelligentized robotic welding as the key technology. The volume is divided into four logical parts: Intelligent Techniques for Robotic Welding, Sensing of Arc Welding Processing, Modeling and Intelligent Control of Welding Processing, as well as Intelligent Control and its Applications in Engineering.Edge Intelligent Computing Systems in Different Domains (SpringerBriefs in Computer Science)
Par Benedetta Picano, Romano Fantacci. 2024
This book provides a comprehensive and systematic exploration of next-generation Edge Intelligence (EI) Networks. It delves deep into the critical…
design considerations within this context, emphasizing the necessity for functional and dependable interactions between networking strategies and the diverse application scenarios. This should help assist to encompass a wide range of environments.This book also discusses topics such as resource optimization, incentive mechanisms, channel prediction and cutting-edge technologies, which includes digital twins and advanced machine learning techniques. It underscores the importance of functional integration to facilitate meaningful collaborations between networks and systems, while operating across heterogeneous environments aiming support novel and disruptive human-oriented services and applications. Valuable insights into the stringent requirements for intelligence capabilities, communication latency and real-time response are discussed. This characterizes the new EI era, driving the creation of comprehensive cross-domain architectural ecosystems that infuse human-like intelligence into every aspect of emerging EI systems.This book primarily targets advanced-level students as well as postdoctoral researchers, who are new to this field and are searching for a comprehensive understanding of emerging EI systems. Practitioners seeking guidance in the development and implementation of EI systems in practical contexts will also benefit from this book.Development and Testing of Vehicle Software and its Influence on Sustainable Transport
Par Antonio Colmenar-Santos, David Borge-Diez, Pedro-Miguel Ortega-Cabezas. 2024
This book evaluates the contributions of the electronic control unit software of an electric vehicle on sustainability and society, such…
as the reduction of emissions during a product design and the improvements in the vehicle. A sustainable transport model is proposed, demonstrating its economic viability. By validating software in a more efficient way and adding new functionalities to the software to enhance driving efficiency, energy consumption can be significantly reduced. Therefore, software validation and development have a significant impact on sustainability. This book offers innovative validation solutions based on artificial intelligence techniques to reduce validation time and emissions. The impact of driving efficiency on sustainable transport models is studied in detail, making proposals to be considered in the current environmental policies under discussion within the European Union in order to improve the sustainability of transport models. Vehicles are becoming sophisticated electronic systems due to the fact that they are integrating a significant number of electronic control units. This trend will certainly continue in the year to come. Consequently, software validation techniques are a key element for car manufacturers in order to ensure the quality of the vehicle. This book contributes to these efforts.Biopharmaceutical Manufacturing: Progress, Trends and Challenges (Cell Engineering #11)
Par Ralf Pörtner. 2023
This volume “Cell Engineerring 11 - Biopharmaceutical Manufacturing: Progress, Trends and Challenges” is a source of the latest innovative research…
and technical development in biomanufacturing systems. It is organised into 2 parts: 1) Manufacturing of recombinant therapeutic proteins (e.g. therapeutic antibodies, biosimilars/biogenerics) and 2) Manufacturing aspects of cell and gene therapy. Each with selected chapters on the following topics for both up- and downstream, such as: Advanced process strategies, especially continuous manufacturing, Advanced culture techniques, especially single-use systems, Process transfer, scale-up/scale-down models, Processing advances/Manufacturing productivity/efficiency, Model-assisted process understanding and development/Digital Twins, Process controls and analytics, Quality control, Quality by design, Facility design and full-scale commercial systems, manufacturing technology innovation.The book comprises contributions of experts from academia and industry active in the field of cell culture development for the production of recombinant proteins, cell therapy and gene therapy, with consideration of Digital Twin´s and facility design. The knowledge and expertise of the authors cover disciplines like cell biology, engineering, biotechnology and biomedical sciences. Inevitably, some omissions will occur in the test, but the authors have sought to avoid duplications by extensive cross-referencing to chapters in other volumes of this series and elsewhere. We hope the volume provides a useful compendium of techniques for scientists in industrial and research laboratories active in this field.Statistics and Data Analysis for Engineers and Scientists (Transactions on Computer Systems and Networks)
Par Tanvir Mustafy, Md. Tauhid Rahman. 2024
This textbook summarizes the different statistical, scientific, and financial data analysis methods for users ranging from a high school level…
to a professional level. It aims to combine the data analysis methods using three different programs—Microsoft Excel, SPSS, and MATLAB. The book combining the different data analysis tools is a unique approach. The book presents a variety of real-life problems in data analysis and machine learning, delivering the best solution. Analysis methods presented in this book include but are not limited to, performing various algebraic and trigonometric operations, regression modeling, and correlation, as well as plotting graphs and charts to represent the results. Fundamental concepts of applied statistics are also explained here, with illustrative examples. Thus, this book presents a pioneering solution to help a wide range of students, researchers, and professionals learn data processing, interpret different findings derived from the analyses, and apply them to their research or professional fields. The book also includes worked examples of practical problems. The primary focus behind designing these examples is understanding the concepts of data analysis and how it can solve problems. The chapters include practice exercises to assist users in enhancing their skills to execute statistical analysis calculations using software instead of relying on tables for probabilities and percentiles in the present world.Road Traffic Analysis, Theoretical Approaches and Practical Solutions (Lecture Notes in Networks and Systems #877)
Par Elżbieta Macioszek, Irena Jurdana, Grzegorz Sierpiński. 2024
This book presents many valuable tips for making decisions related to road traffic in transport networks. The knowledge base in…
practical examples, as well as the decision support systems described in this volume, finds interest among people who face the daily challenge of searching for advanced solutions and practical applications in road traffic engineering. The publication is therefore addressed to local authorities related to the planning and development of development strategies for selected areas with regard to transport (both in the urban and regional dimension) and to representatives of business and industry, as people directly involved in the implementation of traffic engineering solutions. The tips contained in individual sections of the publication allow to look at a given problem in an advanced way and facilitate the selection of the appropriate strategy (among others, in relation to the heuristic approach to assessing the performance efficiency of road intersections in urban environments from the resilience perspective, modeling the distribution of transport pollutants in a naturally ventilated road tunnel, development of a camera-based parking monitoring system with an automatic parking spot identification). In turn, due to a new approach to theoretical models (including, inter alia, problems with the safety of passengers at tram stops or energy-efficient radio platforms for the implementation of nodes of sensor networks), the publication also interests scientists and researchers carrying out research in this area. The publication entitled "Road Traffic Analysis, Theoretical Approaches and Practical Solutions" contains selected papers submitted to and presented at the 19th “Transport Systems. Theory and Practice” Scientific and Technical Conference organized by the Department of Transport Systems, Traffic Engineering and Logistics at the Faculty of Transport and Aviation Engineering at the Silesian University of Technology. The conference took place on September 18–19, 2023, in Katowice (Poland).Vehicle Vibrations: Linear and Nonlinear Analysis, Optimization, and Design
Par Reza N. Jazar, Hormoz Marzbani. 2024
Vehicle Vibrations: Linear and Nonlinear Analysis, Optimization, and Design is a self-contained textbook that offers complete coverage of vehicle vibration topics…
from basic to advanced levels. Written and designed to be used for automotive and mechanical engineering courses related to vehicles, the text provides students, automotive engineers, and research scientists with a solid understanding of the principles and application of vehicle vibrations from an applied viewpoint. Coverage includes everything you need to know to analyze and optimize a vehicle’s vibration, including vehicle vibration components, vehicle vibration analysis, flat ride vibration, tire-road separations, and smart suspensions.Advances in Applied Nonlinear Dynamics, Vibration, and Control – 2023: The Proceedings of 2023 International Conference on Applied Nonlinear Dynamics, Vibration, and Control (ICANDVC2023) (Lecture Notes in Electrical Engineering #1152)
Par Xingjian Jing, Hu Ding, Jinchen Ji, Daniil Yurchenko. 2024
This book provides readers with up-to-date advances in applied and interdisciplinary engineering science and technologies related to nonlinear dynamics, vibration,…
control, robotics, and their engineering applications, developed in the most recent years. All the contributed chapters come from active scholars in the area, which cover advanced theory and methods, innovative technologies, benchmark experimental validations and engineering practices. Readers would benefit from this state-of-the-art collection of applied nonlinear dynamics, in-depth vibration engineering theory, cutting-edge control methods and technologies and definitely find stimulating ideas for their on-going R&D work. This book is intended for graduate students, research staff, and scholars in academics and also provides useful hand-up guidance for professionals and engineers in practical engineering missions.Investing in a Changing Climate: Navigating Challenges and Opportunities (Professional Practice in Governance and Public Organizations)
Par Ludovic Subran, Markus Zimmer. 2023
Net Zero is not enough. We have dithered so long about climate change that, by now, we would need to…
go to negative-emissions territory, well before 2050, to keep global warming under the iconic 1.5°C target. The national commitments made so far fall short of what is needed, and so do the investments envisioned. But even with the best of intentions, it is hard for policymakers and potential investors to discern where, in the profusion of initiatives and technologies, it would make sense to focus their attention and resources. This is where this book comes in. It offers a clear-eyed view of how far along the decarbonization path six key sectors of the economy are—namely energy, utilities, transportation, industry, buildings, and agriculture—and which areas and technologies within each sector are promising in terms of investments to advance the cause. Furthermore, a special chapter on Africa spotlights a continent that is simultaneously one of the worst affected by climate change, the most likely to see its greenhouse gas emissions increase—and the one with the greatest potential for solving the West's, and the world’s, energy transition and economic growth conundrum. As such, the book serves as a concise guide both to the state of the battle against global warming, and for investors, professionals, and policymakers to find their way through the maze of options.Genetic improvement of Small Millets
Par Sweta Mishra, Shailesh Kumar, R C Srivastava. 2024
This book brings out a comprehensive collection of information on small millets. The main focus of this book is to…
introduce the various types of long forgotten small millets to the readers, their genetics, botany and diversity, cultivation, breeding strategies, genomic resources available, how they can be incorporated into the existing cropping systems, their processing strategies and value addition to incorporate into daily diet of humans. It covers finger millet, foxtail millet, proso millet, barnyard millet, little millet, kodo millet, and browntop millet. Millets originated before 10000 BC and were consumed by humans across civilizations until the green revolution took place in India and other developing countries. After green revolution, due to the advent of high-yielding varieties, as the area, production, and market of wheat and rice increased, the acreage of millets gradually decreased. However, with increasing lifestyle diseases, humans have recognized the potential of small millets crop. It is now being considered as super food and smart food as they are nutri-packed and rich in calcium, phosphorous, iron, zinc, and fiber, which is much higher than that available in wheat and rice. This book is of interest to the students, research scholars, national and international agricultural scientists, millet professionals, and food industryThis fully updated second edition outlines the currently available clinical, epidemiological and experimental data on Clostridioides difficile infections(CDI) with special emphasis on…
studies and results achieved in Europe. The incidence and severity of CDI has increased significantly over the last decade, and the book explains why C. difficile, recently reclassified as Clostridioides difficile, remains a significant challenge, also from economic perspective, to health care systems all over the world. The different reservoirs of this ubiquitous microorganism are reviewed as well as the different factors contributing to its virulence, such as toxins and biofilm formation. The rapid evolution of antibiotic resistance is clearly a concern and in a specific way can influence the CDI epidemiology. Additionally, new emerging strains and comparative genomics studies are taken into consideration for their relevance from epidemiological and evolutionary point of view. The book also gives an overview on diagnostics, therapy and surveillance, all of which are still challenging. Therefore, a closer look is taken on the effect of probiotics as an alternative to antibiotics, for prevention and treatment of CDI. Fecal transplantation from healthy donors, passive immunotherapies and vaccines for patients with recurrences are also discussed in dedicated chapters. New topics included sporulation and membrane vesicles in C. difficile. The book closes with a summary of the history and the achievements of the European Society of Clinical Microbiology and Infectious Diseases Study Group for Clostridium difficile (ESGCD) written by the current and past presidents of the Society. It is the aim of this book to raise awareness on CDI and to disseminate updated information on its prevention, diagnosis and treatment.Scientific American Environmental Science for a Changing World, Digital Update
Par Susan Karr. 2024
Real people. Real stories. Real science.Scientific American Environmental Science for a Changing World 4e Digital Update uses magazine-style stories and…
cutting-edge digital resources to help you understand how the science of environmental science works.Proceedings of the 6th International Conference on Advances in Civil Engineering: ICACE 2022 (Lecture Notes in Civil Engineering #368)
Par Scott Arthur, Masato Saitoh, Asiful Hoque. 2024
This book consists of select proceedings of the 6th International Conference on Advances in Civil Engineering (ICACE 2022), covering various…
fields of civil engineering. Various topics covered in this book are construction and building materials, eco-friendly ground improvement, waste disposal technique, waste management, the durability of different concrete structures, environmental impact studies in relation to covid-19 pandemic, various aspects of foundation engineering, transport planning scenario in developing countries, highway materials and many more. The book will be for researchers and professionals working in the area of civil engineering.