Résultats de recherche de titre
Articles 1 à 20 sur 1597
Murdered Midas: a millionaire, his gold mine, and a strange death on an island paradise /
Par Charlotte Gray. 2019
On an island paradise in 1943, Sir Harry Oakes, gold mining tycoon, philanthropist and "richest man in the Empire," was…
murdered. The news of his death surged across the English-speaking world, from London, the Imperial centre, to the remote Canadian mining town of Kirkland Lake, in the Northern Ontario bush. The murder became celebrated as "the crime of the century." The layers of mystery deepened as the involvement of Oakes' son-in-law, Count Alfred de Marigny, came quickly to be questioned, as did the odd machinations of the Governor of the Bahamas, the former King Edward VIII. Despite a sensational trial, no murderer was ever convicted. Rumours were unrelenting about Oakes' missing fortune, and fascination with the Oakes story has persisted for decades. Award-winning biographer and popular historian Charlotte Gray explores, for the first time, the life of the man behind the scandal, a man who was both reviled and admired - from his early, hardscrabble days of mining exploration, to his explosion of wealth, to his grandiose gestures of philanthropy. And Gray brings fresh eyes to the bungled investigation and shocking trial in the remote colonial island streets, proposing an overlooked suspect in this long cold case. 2019.Trudeau: the education of a prime minister /
Par John Ivison. 2019
Canadians are very divided about their chameleon prime minister. Is Justin Trudeau a transformative prime minister, or does he just…
play one on television? When he entered politics, he came across as a frivolous person with no fixed principles. Now, he presents himself as a conviction politician. Is he real or phony? What motivated his metamorphosis--belief or opportunism? More prosaically, he appears a man of good intentions but in 2019, he will be judged on results. And those results have been disappointing for many, even in his own party. The ballooning deficit, the Trans Mountain Pipeline, his disastrous trip to India, the carbon tax, and many other miscalculations have done him and his party no favours. And while the Liberals concluded a new trade deal with the United States and Mexico, there are still many Canadians dissatisfied with the terms. As political columnist for the National Post since 2003 and Ottawa bureau chief for Postmedia for the past three years, John Ivison has watched Trudeau evolve as a politician and leader at home and abroad. He first interviewed him in 2006 and has sat down on a number of occasions since. It has been a fascinating transition that has not been fully captured by any writer. This book will trace the palimpsest of the man, now barely visible beneath the talking points, virtue signalling, and polished trappings of office. Ivison concludes that he has always been manipulative--good at understanding the feelings of others and playing on them. It has made him a formidable politician but one who may yet be undone by raising the bar too high; by promising to transform a country that was designed to withstand change. 2019.Girls need not apply: field notes from the Forces /
Par Kelly S. Thompson. 2019
At eighteen years old, Kelly Thompson enlisted in the Canadian Armed Forces. Despite growing up in a military family --…
she would, in fact, be a fourth-generation soldier -- she couldn't shake the feeling that she didn't belong. From the moment she arrives for basic training at a Quebec military base, a young woman more interested in writing than weaponry, she quickly realizes that her conception of what being a soldier means, forged from a desire to serve her country after the 9/11 attacks, isn't entirely accurate. A career as a female officer will involve navigating a masculinized culture and coming to grips with her burgeoning feminism. In this compulsively readable memoir, Thompson writes with wit and honesty about her own development as a woman and a soldier, unsparingly highlighting truths about her time in the military. In sharply crafted prose, she chronicles the frequent sexism and misogyny she encounters both in training and later in the workplace, and explores her own feelings of pride and loyalty to the Forces, and a family legacy of PTSD, all while searching for an artistic identity in a career that demands conformity. When she sustains a career-altering injury, Thompson fearlessly re-examines her identity as a soldier. 2019.Daughter of Family G: a memoir of cancer genes, love and fate /
Par Ami McKay. 2019
The story of Ami McKay's connection to a genetic disorder called Lynch syndrome begins over seventy years before she was…
born and long before scientists discovered DNA. In 1895 her great-great aunt, Pauline Gross, a seamstress in Ann Arbor, Michigan, confided to a pathology professor at the local university that she expected to die young, like so many others in her family. Rather than dismiss her fears, the pathologist chose to enlist Pauline in the careful tracking of those in her family tree who had died of cancer. Pauline's premonition proved true--she died at 46--but because of her efforts, her family (who the pathologist dubbed 'Family G') would become the longest and most detailed cancer genealogy ever studied in the world. A century after Pauline's confession, researchers would identify the genetic mutation responsible for the family's woes. Now known as Lynch syndrome, the genetic condition predisposes its carriers to several types of cancer, including colorectal, endometrial, ovarian and pancreatic. In 2001, as a young mother with two sons and a keen interest in survival, Ami McKay was among the first to be tested for Lynch syndrome. She had a feeling she'd test positive: her mother's side of the family was riddled with early deaths and her own mother was being treated for the disease. When the test proved her fears true, she began living in "an unsettling state between wellness and cancer," and she's been there ever since. 2019.High school /
Par Sara Quin. 2019
High School is the revelatory and unique coming-of-age story of Sara and Tegan Quin, identical twins from Calgary, Alberta, growing…
up in the height of grunge and rave culture in the 90s, well before they became the celebrated musicians and global LGBTQ icons we know today. While grappling with their identity and sexuality, often alone, they also faced academic meltdown, their parents' divorce, and the looming pressure of what might come after high school. Written in alternating chapters from both Tegan's point of view and Sara's, the book is a raw account of the drugs, alcohol, love, music, and friendship they explored in their formative years. A transcendent story of first loves and first songs, it captures the tangle of discordant and parallel memories of two sisters who grew up in distinct ways even as they lived just down the hall from one another. 2019.From the ashes: my story of being Métis, homeless, and finding my way
Par Jesse Thistle. 2019
Abandoned by his parents as a toddler, Jesse Thistle briefly found himself in the foster-care system with his two brothers,…
cut off from all they had known. Eventually the children landed in the home of their paternal grandparents, but their tough-love attitudes meant conflicts became commonplace. And the ghost of Jesse's drug-addicted father haunted the halls of the house and the memories of every family member. Struggling, Jesse succumbed to a self-destructive cycle of drug and alcohol addiction and petty crime, spending more than a decade on and off the streets, often homeless. One day, he finally realized he would die unless he turned his life around. 2019.We have always been here: a queer Muslim memoir /
Par Samra Habib. 2019
Growing up in Pakistan, Samra Habib lacks a blueprint for the life she wants. She has a mother who gave…
up everything to be a pious, dutiful wife and an overprotective father who seems to conspire against a life of any adventure. Plus, she has to hide the fact that she's Ahmadi to avoid persecution from religious extremists. As the threats against her family increase, they seek refuge in Canada, where new financial and cultural obstacles await them. When Samra discovers that her mother has arranged her marriage, she must again hide a part of herself--the fun-loving, feminist teenager that has begun to bloom--until she simply can't any longer. So begins a journey of self-discovery that takes her to Tokyo, where she comes to terms with her sexuality, and to a queer-friendly mosque in Toronto, where she returns to her faith in the same neighbourhood where she attended her first drag show. Along the way, she learns that the facets of her identity aren't as incompatible as she was led to believe, and that her people had always been there--the world just wasn't ready for them yet. 2019.Mistakes to run with: a memoir /
Par Yasuko Thanh. 2019
Mistakes to Run With chronicles the turbulent early years of Yasuko Thanh's life, from a rough childhood to her teen…
years as a sex worker to her emergence as a writer. Growing up in a housing project in Victoria, BC, Thanh rebels against her extremely religious parents. She's an honours student, but also a nascent delinquent, cutting herself and getting arrested for shoplifting. By fifteen her parents have kicked her out. She runs away repeatedly from foster homes, acquiring a taste for drugs and alcohol and learning unlikely lessons about sex, power, and friendship. By the time she enters the world of sex work she feels completely abandoned--by her family, her friends, her school, and society. After a stint in jail at sixteen, she meets her pimp, Jesse, and falls in love. The next chapter of her life takes us from the motel rooms of Victoria to the streets of Vancouver, as Thanh endures further hardship: beatings, arrests, Jesse's crack cocaine addiction, and an unwanted pregnancy. It's the act of writing that ultimately becomes a solace from her suffering--but even as publication and awards bolster her, she remains haunted by her past. 2019.Treatment of Thyroid Tumor
Par Hitoshi Noguchi, Takahiro Okamoto, Yasuhiro Ito, Hiroshi Takami, Akira Yoshida. 2012
Creating clinical guidelines is a modern trend. Published studies pertaining to a given theme are collected, their credibility evaluated, and…
then treatment options in the form of evidence-based guidelines are offered. There are a number of guidelines for the treatment of thyroid tumors that have established positions in clinical practice in North America and in Western European countries. In Japan, however, where radioisotope facilities are of limited availability, treatment plans for differentiated thyroid cancer differ considerably from those of America and Europe, and the associated clinical guidelines need modification before they can be adopted. In addition, although thyroid tumor is a common disease in endocrine practice, its management can differ even among specialists. Thus, a Japanese clinical guideline for the treatment of thyroid tumor was desired by many clinicians. As a combination of evidence-based and consensus-based guidelines for the treatment of thyroid tumor, this book offers alternatives to conventional approaches in the West. Ultimately, the authors hope the guideline will lead to the best possible treatment for patients all over the world in the not-distant future.Everything You Need to Know to Manage Type 2 Diabetes: Simple Steps for Surviving and Thriving with the Low GI Plan
Par Kaye Foster-Powell, Jennie Brand-Miller, Stephen Colagiuri, Alan Barclay. 2007
A practical, easy-to-use guide to help you manage type 2 diabetes or prediabetes If you are one of the millions…
of people living with diabetes or prediabetes, you may feel like you're inundated with information on how to manage your condition. The good news is that we now know a lot more about managing diabetes or reducing your risk of developing it--and here, the world's foremost glycemic index experts share their wisdom. Rather than blind you with science or swamp you with facts, Everything You Need to Know to Manage Type 2 Diabetes sets out clearly and simply what you need to eat and do to help you: Reduce your risk of developing diabetes Improve your insulin sensitivity and your cardiovascular health Keep your blood glucose levels, blood pressure, and blood fats under control Reduce your body fat and maintain a healthy body With tips and strategies for working with your doctor, the most recent info on medications, and guidance on the best foods to eat (at home or at a restaurant), Everything You Need to Know to Manage Type 2 Diabetes offers uncomplicated, straightforward advice to help you survive--and thrive.Low GI Diet: Managing Type 2 Diabetes
Par Kaye Foster-Powell, Jennie Brand-Miller. 2014
The revised edition of the essential handbook on how to reduce the health risks posed by Type 2 Diabetes -…
from the team behind the internationally bestselling Low GI series. Are you living with type 2 diabetes or pre-diabetes and trying to manage your condition? In Australia and New Zealand alone diabetes and pre-diabetes affect 1 in 4 people. Every day nearly 300 people, including children, develop type 2 diabetes and for every person diagnosed with diabetes there's someone else with undiagnosed diabetes. The good news is that we now know a lot more about managing diabetes or reducing your risk of developing it. Low GI Diet: Managing Type 2 Diabetes cuts through the confusion of conflicting advice and sets out clearly and simply what you need to eat and do to help you: reduce your risk of developing diabetes; improve your cardiovascular health; keep your blood glucose levels, blood pressure and blood fats under control; and maintain a healthy body. This book is a practical guide to help you manage your diabetes or pre-diabetes with diet and lifestyle from the highly qualified, specialist team of authors led by world Low GI authority Professor Jennie Brand-Miller. It shows what you can do for yourself - and why. Best of all, this information is good advice for everyone in your family, not just you.Diabetes and Cardiovascular Disease
Par Francesco Paneni, Francesco Cosentino. 2015
This book provides a practical hands-on approach to the management of patients with diabetes and cardiovascular disease, with original and…
up-to-date coverage of a variety of aspects of emerging clinical importance. Practical advice is offered on diagnosis, risk stratification, management of cardiovascular risk factors and available drug therapies. Appropriate myocardial revascularization strategies are explained and the current state of knowledge is documented regarding target-led multifactorial treatment and the management of acute coronary syndromes, heart failure, and cerebrovascular disease. New algorithms for diagnosis and treatment are presented and to ensure ease of reference each chapter includes a box with practical recommendations as well as informative color illustrations and tables. The handbook will be of value for all cardiologists and diabetologists and will be especially helpful for young cardiologists, who are ever more frequently confronted by patients with diabetes and cardiovascular disease.Genetic Damage in Human Spermatozoa
Par Monica Muratori, Elisabetta Baldi. 2014
There are several types of damage that can be found in the male gamete. Genetic damage in spermatozoa can originate…
during spermatogenesis, or it can originate during transit in both male and female genital tracts. Damage can also be due to ageing, environmental or iatrogenic conditions, as well as to the protocols to cryopreserve and to select spermatozoa in assisted reproduction techniques. The purpose of this book is to provide a comprehensive resource for all possible DNA damages in sperm, the relation to fertility and infertility, and possible transgenerational heritable effects.Thymic Development and Selection of T Lymphocytes
Par Thomas Boehm, Yousuke Takahama. 2014
The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place.…
Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.Obesity and Breast Cancer
Par Kristy A. Brown, Evan R. Simpson. 2014
Obesity is a risk factor for breast cancer in older women. A number of adipose-derived and obesity-related factors have been…
shown to affect tumour cell growth. These include adipokines, insulin, IGF-1 and oestrogens. The majority of obesity-related postmenopausal breast cancers are oestrogen-dependent. Since the ovaries no longer produce oestrogens after menopause, and that circulating levels are negligible, it is evident that it is the oestrogens produced locally within the breast adipose that are responsible for the increased growth of breast cancer cells. Aromatase is the enzyme that converts androgens into oestrogens and its regulation is dependent on the activity of a number of tissue-specific promoters. Targeting oestrogen biosynthesis in obesity may be useful for the prevention of breast cancer. Aromatase inhibitors are efficacious at treating postmenopausal breast cancer and recent studies suggest that they may also be useful in the prevention setting. However, these compounds inhibit the catalytic activity of aromatase and as a consequence lead to a number of undesirable side-effects, including arthralgia and possible cognitive defects due to inhibition of aromatase in the bone and brain, respectively. Novel therapies, such as those employed to treat obesity-associated disease, including anti-diabetics, may prove successful at inhibiting aromatase specifically within the breast. This SpringerBrief will explore all of these issues in depth and the authors are in a unique position to write about this topic, having extensive experience in the field of aromatase research.The Cleveland Clinic Manual of Dynamic Endocrine Testing
Par Ahmet Bahadir Ergin, A. Laurence Kennedy, Manjula K. Gupta, Amir H. Hamrahian. 2015
Developed via a peer review process that included 25 experienced endocrinologists and utilizing the best current evidence, The Cleveland Clinic…
has created a practical set of protocols for over 25 commonly used dynamic endocrine tests. The cornerstone of clinical endocrinology, these evidence-based protocols play an important role in clinical decision-making and are important element of billing and compliance with high quality standards. Included here are various tests for pituitary and adrenal disorders, thyroid disorders, and glucose metabolism and pancreatic disorders, presented systematically with indications, preparation, materials needed, precautions, procedure, interpretation, and caveats. Filling the gap left by a lack of national guidelines, The Cleveland Clinic Manual of Dynamic Endocrine Testing is an up-to-date practical guide for endocrinologists, nurses, and their staff, inside or outside of the US, who need to perform and interpret dynamic endocrine testing in their everyday practice, as well as medical students, residents and fellows who have interest in endocrinology.Stem Cell Therapy in Lysosomal Storage Diseases
Par Jaap Jan Boelens, Robert Wynn. 2013
Stem Cell therapy for lysosomal diseases (LSDs) is developing rapidly. This volume discusses the history, current practice and future perspectives…
of stem cells in inborn errors of metabolism (IEM) and provides an international perspective on progress, limitations, and future directions (e. g. gene therapy, iPS, ES) in the field. Beginning with an overview of these diseases, the book covers the breadth of this topic from treatment options, bone marrow transplantation, and alternative treatment options, through long-term outcomes and future perspectives.Therapeutic Perspectives in Type-1 Diabetes
Par Prachi Singh, Ganesh R Kokil, Karnaker R Tupally, Kingshuk Poddar, Aaron Tan, Venky Venkatesan, Harendra S. Parekh, Giorgia Pastorin. 2016
This book provides critical insights into and appraisals ofrecent breakthroughs in type 1 diabetes modulation, with a particular emphasison the…
potential impact of current prevention and treatment strategies. It alsodiscusses recent successes and failures in clinical trials. Presenting ancomprehensive overview of the disease, it is especially useful for newcomers inthe field. It also includes illustrations, which make it easy for the reader tograsp the basic concepts involved. Furthermore, the tables include concise andeasy-to-understand information on current clinical trials.Diabetes Management in Clinical Practice
Par Tahseen A. Chowdhury. 2014
At a time when clinicians are bombarded with masses of clinical information from numerous sources, and the wide variety of…
changes/advances in diabetes management, there is a need for a concise, easy-to-read book that provides an up-to-date review of the major advances in management of diabetes, with an evidence-based approach. This book is a collection of short chapters, each focused on a subject related to the management of diabetes and its complications. The chapters are written by acknowledged experts in the field, who are also clinicians dealing with diabetes on a day-to-day basis. The text is highly evidence based and well referenced with reviews of relevant trials. It includes the latest developments in diabetes management, prospects for future therapies and avenues of research, as well as therapies currently undergoing clinical trial. In order to facilitate ease of reading, it has a user-friendly appearance, with multiple headings, illustrations and summary boxes. The primary audience is clinical, including all healthcare professionals involved in the management of diabetes and its complications. This encompasses diabetologists and endocrinologists, family practitioners with an interest in diabetes, specialist nurses, dietitians and podiatrists.Glycemic Control in the Hospitalized Patient
Par Lillian F. Lien, Leonor Corsino, Mark N. Feinglos, Mary E. Cox. 2011
Glycemic Control in the Hospitalized Patient: A Comprehensive Clinical Guide is a unique, practical resource for health care providers dealing…
with hyperglycemia in the inpatient setting. Outlining a hands-on approach used by the Duke University Inpatient Diabetes Management team, the book discusses a wide range of scenarios that occur while treating patients with hyperglycemia, including challenging circumstances such as steroids and tube feeding regimens. Special emphasis is given to insulin therapy. The chapters are written by a group of health care providers with extensive, pioneering experience in hyperglycemia control in the inpatient setting at the Duke University Medical Center. The book includes the most up-to-date scientific evidence and information and is addressed to not only hospitalists and general internists but also endocrinology fellows, residents, nurse practitioners, nurses, and other primary care practitioners who treat patients in the inpatient setting. The focus is clearly on practical, patient-care topics. Glycemic Control in the Hospitalized Patient: A Comprehensive Clinical Guide is a first-of-its kind, comprehensive guide to state-of-the-art inpatient glycemic management.