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A Concise Guide to Clinical Trials
Par Allan Hackshaw. 2024
Design and execute life-saving trials with this accessible resource Clinical trials have revolutionized the treatment of disease and the development…
of life-saving pharmaceuticals. They contribute decisively to diagnosis, the avoidance of early death, medical intervention and are central to the modern work of pharmaceutical producers. The design and execution of clinical trials is one of the fastest-growing and most important areas of medical and pharmaceutical research. A Concise Guide to Clinical Trials provides an accessible and comprehensive survey of clinical trials, their design, and their applications. Beginning with a taxonomy of trial types, the book overviews stages of analysis, ethical and legal requirements, and more. Now fully updated to reflect the latest research and clinical practice, it continues to be an indispensable resource for researchers and clinicians. Readers of the second edition of A Concise Guide to Clinical Trials will also find: New material on pharmaceutical trials, adaptive designs, and the use of “big data” The easy-to-use organization facilitates both first-time learning and reference Detailed treatment of concepts such as health technology assessments (HTA), patient and public involvement and engagement (PPIE), and more A Concise Guide to Clinical Trials is ideal for clinicians and healthcare professionals looking for a working knowledge of clinical trials, as well as for pharmaceutical workers and regulators looking to understand this vital aspect of the industry.The Art of Dying Well: A Practical Guide to a Good End of Life
Par Katy Butler. 2019
This &“comforting…thoughtful&” (The Washington Post) guide to maintaining a high quality of life—from resilient old age to the first inklings…
of a serious illness to the final breath—by the New York Times bestselling author of Knocking on Heaven&’s Door is a &“roadmap to the end that combines medical, practical, and spiritual guidance&” (The Boston Globe).&“A common sense path to define what a &‘good&’ death looks like&” (USA TODAY), The Art of Dying Well is about living as well as possible for as long as possible and adapting successfully to change. Packed with extraordinarily helpful insights and inspiring true stories, award-winning journalist Katy Butler shows how to thrive in later life (even when coping with a chronic medical condition), how to get the best from our health system, and how to make your own &“good death&” more likely. Butler explains how to successfully age in place, why to pick a younger doctor and how to have an honest conversation with them, when not to call 911, and how to make your death a sacred rite of passage rather than a medical event. This handbook of preparations—practical, communal, physical, and spiritual—will help you make the most of your remaining time, be it decades, years, or months. Based on Butler&’s experience caring for aging parents, and hundreds of interviews with people who have successfully navigated our fragmented health system and helped their loved ones have good deaths, The Art of Dying Well also draws on the expertise of national leaders in family medicine, palliative care, geriatrics, oncology, and hospice. This &“empowering guide clearly outlines the steps necessary to prepare for a beautiful death without fear&” (Shelf Awareness).Healing Arthritis: Your 3-Step Guide to Conquering Arthritis Naturally
Par Susan Blum. 2017
The author of the bestselling The Immune System Recovery Plan shares her science-based, drug-free treatment plan for the almost fifty…
million people who suffer from arthritis: an amazing 3-step guide to eliminate the disease naturally.Arthritis is the most common cause of disability in the world—greater than both back pain and heart disease. One example, Rheumatoid Arthritis (RA), is the most common autoimmune disease, affecting 1% of the US population, and almost 68 million people worldwide. Conventional medicine tends to treat arthritis with strong, gut-damaging, immune-suppressing pain medications, temporarily relieving the symptoms of the disease without addressing its root causes. Now, in her groundbreaking new book, Dr. Susan Blum, a leading expert in functional medicine, offers a better approach to healing arthritis permanently. Dr. Blum&’s groundbreaking three-step protocol is designed to address the underlying causes of the condition and heal the body permanently by: -Treating Rheumatoid Arthritis, Osteoarthritis, and more -Healing your gut to heal your joints -Reducing inflammation without medication Dr. Blum&’s innovative two-week plan to quickly reduce pain through anti-inflammatory foods and supplements; followed by an intensive gut repair to rid the body of bad bacteria and strengthen the gastrointestinal system for a dramatic improvement in arthritis symptoms and inflammation; and then addresses the emotional issues that contribute to inflammation, and eating a simple, Mediterranean inspired diet to maintain a healthy gut. Featuring detailed case studies, including Dr. Blum&’s own inspiring personal story, Healing Arthritis offers a revolutionary way to heal your gut, repair your immune system, control inflammation, and live a happier, healthier life…arthritis-free.Exercise Physiology: for Health and Sports Performance
Par Nick Draper, Craig Williams, Helen Marshall. 2024
This second edition of Exercise Physiology: For Health and Sports Performance brings together all the essential human anatomy and applied…
physiology that students of exercise science, physical education, and sports coaching will need to know.Written in a friendly, accessible style, and containing a wide range of features to help develop understanding, this book provides a complete one-stop shop for exercise physiology broken down into three fundamental parts: foundations of exercise physiology, applied exercise physiology, and the new Part 3, exercise prescription.With Parts 1 and 2 examining the theory, testing, and practical applications of exercise physiology, the new Part 3 reflects the changes in the field by increasing focus on physical activity and diverse populations and helps provides a more complete course text for any exercise physiology course at universities around the world.This newly revised book is key reading for undergraduate and postgraduate students in the fields of exercise physiology, sports performance, sports therapy, fitness and personal training, and other related sport science courses.Augmented Reality Games II: The Gamification of Education, Medicine and Art
Par Vladimir Geroimenko. 2024
This is the second edition of the first ever research monograph that explores the exciting field of augmented reality games…
and their enabling technologies. The new edition has been thoroughly revised and updated, with 6 new chapters included. As well as investigating augmented reality games in education, the book covers the gamification of medicine, healthcare, and art. It has been written by a team of 43 researchers, practitioners, and artists from 12 countries, pioneering in developing and researching the new type of computer games.This book deals with a systematic analysis of educational augmented reality games, the gamification of elementary and secondary education, teachers’ novel key skills and new teaching methods in the classroom, creating immersive and playful reading experiences, augmented reality games for health promotion in old age and for transforming dental and physical education and practice, the gamification of augmented reality art, pervasive games, and gaming in public spaces, among other topics.Intended as a starting point for exploring this new fascinating area of research and game development, it will be essential reading not only for researchers, practitioners, game developers, and artists, but also for students (graduates and undergraduates) and all those interested in the rapidly developing area of augmented reality games.Big Data Analytics: Theory, Techniques, Platforms, and Applications
Par Ümit Demirbaga, Gagangeet Singh Aujla, Anish Jindal, Oğuzhan Kalyon. 2024
This book introduces readers to big data analytics. It covers the background to and the concepts of big data, big…
data analytics, and cloud computing, along with the process of setting up, configuring, and getting familiar with the big data analytics working environments in the first two chapters. The third chapter provides comprehensive information on big data processing systems - from installing these systems to implementing real-world data applications, along with the necessary codes. The next chapter dives into the details of big data storage technologies, including their types, essentiality, durability, and availability, and reveals their differences in their properties. The fifth and sixth chapters guide the reader through understanding, configuring, and performing the monitoring and debugging of big data systems and present the available commercial and open-source tools for this purpose. Chapter seven gives information about a trending machine learning, Bayesian network: a probabilistic graphical model, by presenting a real-world probabilistic application to understand causal, complex, and hidden relationships for diagnosis and forecasting in a scalable manner for big data. Special sections throughout the eighth chapter present different case studies and applications to help the readers to develop their big data analytics skills using various big data analytics frameworks.The book will be of interest to business executives and IT managers as well as university students and their course leaders, in fact all those who want to get involved in the big data world.Rare Genetic Disorders: Advancements in Diagnosis and Treatment
Par Muhammad Umair, Misbahuddin Rafeeq, Qamre Alam. 2024
This book introduces different Rare Genetic Disorders (RGDs), and challenges in their diagnosis. The chapters of the book discuss the…
emerging research and clinical approaches for the diagnosis of rare genetic disorders. It further reviews the future of genetic therapies for the treatment of rare genetic diseases and examine the recent advancements in the field of genetic testing for the diagnosis of these diseases. The book also covers the role of variants in the genome (genetic modifiers) that alleviate (suppress) or exacerbate (enhance) the severity of the disease, resulting in the variability of phenotypic outcomes. Further, the book examines different animal models for critical understanding of disease mechanisms, and the opportunity to evaluate the effect of therapeutic compounds in pre-clinical studies. The subsequent chapters present the state-of-the-art drug discovery strategies and biological approaches for the treatment of rare genetic disorders. Towards the end, the book reviews the current challenges in the diagnosis and treatment of the patients of rare genetic disorders and future opportunities. This book is useful for clinical geneticists, molecular and biochemical geneticists, researchers working in gene therapy and genome editing.Family-School Success for Children with ADHD: A Guide for Intervention (The Guilford Practical Intervention in the Schools Series)
Par Thomas J. Power, Jennifer A. Mautone, Stephen L. Soffer. 2024
Distilling decades of research, this practical manual presents an innovative intervention for families of 6- to 10-year-olds (grades 1–5) with…
attention-deficit/hyperactivity disorder (ADHD). Family–School Success (FSS) focuses on improving children's behavior and academic performance by strengthening parent–child, teacher–student, and family–school relationships. Detailed guidelines are provided for implementing FSS with parent groups or individual families, including how to involve children in groups and collaborate with teachers. The authors discuss ways to deliver FSS effectively in school- and clinic-based settings, private practice, and primary care. In a convenient large-size format, the book features dozens of reproducible parent handouts and worksheets, assessment tools, and fidelity checklists, which can also be downloaded and printed. This book is in The Guilford Practical Intervention in the Schools Series, edited by Sandra M. Chafouleas.Between Heaven and Hell: The Story of My Stroke
Par David Talbot. 2020
Acclaimed writer, bestselling author, and founder of Salon magazine, David Talbot has brought us masterful and explosive headline-breaking stories for…
over 25 years with books like the New York Times bestsellers Brothers, The Devil's Chessboard, and nationally recognized Season of the Witch. Now for the first time, journalist and historian David Talbot turns inward in this intimate journey through the life-changing year following his stroke, a year that turned his life upside down, and ultimately, saved him. • A portrait of how a health crisis can truly shift one's perspective on life and purpose• Includes insider stories on the wild early days of Internet journalism, tech culture, and Hollywood• Powerful storytelling of the physical, emotional, and psychological impact a stroke has had on the author's identityFans of My Stroke of Insight, The Devil's Chessboard and Season of the Witch will love this book. This book is perfect for:• Fans of David Talbot• Anyone dealing with or recovering from health issues (particularly stroke or brain injury) and looking for insight and inspiration• Gen Xers and baby boomers who understand their risk for stroke• Entrepreneurs scared of burnoutKrause's Food And The Nutrition Care Process
Par L. Kathleen Mahan, Sylvia Escott-Stump, Janice L. Raymond. 2012
Diary of a Dying Girl: Adapted from Salt in My Soul
Par Mallory Smith. 2024
This collection of one girl's real, unflinching diary entries about slowly dying of a terminal illness is an unparalleled exploration…
of the human spirit and what it means to truly live.Many of the feelings I write about are too difficult to share while I'm alive, so I'm keeping everything in my journal password-protected until the end.Mallory Smith was no ordinary girl, and this is no ordinary story. At age three, Mallory was diagnosed with cystic fibrosis--a disease that attacks the internal organs and would eventually kill her. Despite living on borrowed time, Mallory pursued her passions: volleyball; writing; the environment; her boyfriend, family, and friends. Most importantly, every day she chose to embody the mantra "live happy." Mallory also had her struggles--everything from love and sex to living with illness and just being a human on this planet. And she chronicled every bit of it, writing thousands of diary entries before her death in her twenties. This is the poignant, true story of a young woman who refused to be defined by chronic illness. Her light and her life are shared here in her own words to encourage everyone to live life to the fullest, as she did, even as she was dying.The inspiring story of a Black doctor who was deeply affected by the violence that plagued his Brooklyn childhood and…
later dedicated himself to addressing trauma and violence as public health issuesRob Gore first encountered violence when he was beaten and robbed as a 10-year old; it was treated as an inevitable fact of life, but after another brush with violence as a teen, he began to reject that prevalent attitude. As he matured and became a doctor, he grew in his determination to find treatments for what he saw not as an unavoidable fact for most people living in vulnerable, underserved neighborhoods especially, but as a public health issue that could be addressed by early intervention and solid support, beginning in the medical community. He also became deeply involved in efforts to diversify the entire field of medicine, starting with the &“front lines&” in the Emergency Department.Seeing his brother Angel and close friend Willis fall prey to the epidemic of violence with profound—and in Willis&’s case—deadly consequences, Rob began seriously researching the issue and went on to found an organization which is one of the models for successful approaches to reducing violence and protecting victims, who are disproportionately BIPOC, living in impoverished neighborhoods, or members of the LGBTQ+ community. Here he provides not only statistics, but stories of what he witnessed in NYC neighborhoods, in Atlanta, Chicago, Buffalo and even in medical work in Haiti and Kenya. His work with the Kings Against Violence Initiate (KAVI) and allied organizations is a blueprint for treating violence not as a police matter, but as a public health crisis, which can and should be addressed and substantially reduced. The people he introduces us to in these pages are not merely victims, but often advocates, paving the way for eliminating the epidemic of violence in our country.Bayesian Precision Medicine (Chapman & Hall/CRC Biostatistics Series)
Par Peter F. Thall. 2024
Bayesian Precision Medicine presents modern Bayesian statistical models and methods for identifying treatments tailored to individual patients using their prognostic…
variables and predictive biomarkers. The process of evaluating and comparing treatments is explained and illustrated by practical examples, followed by a discussion of causal analysis and its relationship to statistical inference. A wide array of modern Bayesian clinical trial designs are presented, including applications to many oncology trials. The later chapters describe Bayesian nonparametric regression analyses of datasets arising from multistage chemotherapy for acute leukemia, allogeneic stem cell transplantation, and targeted agents for treating advanced breast cancer.Features: Describes the connection between causal analysis and statistical inference Reviews modern personalized Bayesian clinical trial designs for dose-finding, treatment screening, basket trials, enrichment, incorporating historical data, and confirmatory treatment comparison, illustrated by real-world applications Presents adaptive methods for clustering similar patient subgroups to improve efficiency Describes Bayesian nonparametric regression analyses of real-world datasets from oncology Provides pointers to software for implementation Bayesian Precision Medicine is primarily aimed at biostatisticians and medical researchers who desire to apply modern Bayesian methods to their own clinical trials and data analyses. It also might be used to teach a special topics course on precision medicine using a Bayesian approach to postgraduate biostatistics students. The main goal of the book is to show how Bayesian thinking can provide a practical scientific basis for tailoring treatments to individual patients.The Minor Illness Manual
Par Gina Johnson, Ian Hill-Smith, Chirag Bakhai, Bhavina Khatani. 2024
This sixth edition of the best-selling The Minor Illness Manual has been completely revised and updated to include the latest…
clinical guidance and prescribing information, with a reworked introductory chapter reflecting the changing demands of primary care and a new chapter added on COVID-19 and pandemics.The simple, clear and easy-to-use format gives primary care professionals – including doctors, nurses, pharmacists, physician associates and paramedics – speedy access to evidence-based guidance for dealing quickly and appropriately with the wide-ranging situations they are likely to encounter in their daily practice.Prescriber's Guide – Children and Adolescents: Stahl's Essential Psychopharmacology
Par null Stephen M. Stahl. 2019
This extensively revised second edition provides a user-friendly step-by-step manual on the range of psychotropic medications prescribed for children and…
adolescents by clinicians and nurse practitioners. Boasting nearly double the medications of the first edition, it features new sections related to pharmacokinetics and pharmacogenetics in children and adolescents alongside algorithms for addressing frequently encountered disorders such as anxiety, depression, bipolar disorder, ADHD, and OCD. Based on the best-seller, Stahl's Prescriber's Guide, and using a full-color template-driven navigation system, it combines evidence-based data with clinically informed guidance to support prescribers in the field. Each drug is presented in the same classic design format with illustrated guidance on dosing, titration, and pharmacogenetics/metabolism. Color-coded sections distinguish clearly the information presented on therapeutics, safety and tolerability, dosing and use, what to expect, and the art of psychopharmacology, and are followed by updated and new key references. A must-have guide for all mental health professionals.Thinking About Medicine: An Introduction to the Philosophy of Healthcare
Par David Misselbrook. 2024
This introduction to the philosophy of medicine surveys the landscape of western philosophy as it pertains to healthcare in an…
accessible way. Written by a doctor for doctors and other health professionals, framing the 'toolbox' of philosophy within the community of medicine, it encourages examination of the implicit assumptions made in the construction of medical knowledge and practice.Taking the reader step by step through the concepts that underpin modern philosophy, they will be challenged to reflect upon the premises within clinical practice which might benefit from scrutiny and challenge, including the nature of scientific knowledge, the limits of our biomedical model, the cultural and relational context, and the failure to recognise or manage adequately the fact/value distinction in medicine and healthcare.The book is an ideal textbook for students of medicine and medical philosophy and will also be of interest to bioethicists, medical sociologists, clinical commissioners and to practicing clinicians in medicine and the allied health professions seeking to improve their understanding of philosophy and ethics and sharpen their critical thinking skills.Von Hippel-Lindau Disease: A Comprehensive Guide to Diagnosis, Treatment, and Management
Par Dhaval Thakor Patel, Amit Tirosh. 2024
Von Hippel-Lindau (VHL) disease is an inherited disorder characterized by the abnormal growth of both benign and cancerous tumors and…
cysts in many parts of the body. Considering the number of manifestations of the VHL disease, screening and management is complex and requires a multidisciplinary effort as well as an understanding of the interplay between all the manifestations. This book is one of the first to provide fundamental knowledge about VHL and the know-how on the various manifestations of this complex syndrome. Various aspects of VHL are reflected in this book's table of contents, written by the leading experts in each field discussed. Comprehensive and easy-to-use, this book offers a detailed and comprehensive analysis of the manifestations and management of patients with VHL and serves as the definitive book on the management of patients with VHL for surgical oncologists, endocrinologists, urologists, neurosurgeons, ophthalmologist, radiologists, and all primary care physicians.While transplanting human heads is not a new concept, the idea has largely been relegated to religious lore or as…
a plot device in science fiction. But now, a surgical plan to perform the complex procedure exists, and though most physicians question head transplantation’s medical veracity, bioethicists have challenged the surgery on moral grounds. A Test of Morals compiles and examines the ethical questions that dog those who advocate for conducting this most radical of medical proposals in order to determine if society should move forward and allow head transplantation to occur. Current bioethical principles stand in opposition to head transplantation, causing a conflict of values rarely seen in medicine.Decluttered: Mindful Organizing for Health, Home, and Beyond
Par Jenny Albertini. 2024
Have you ever wondered why you can't summon the energy to declutter those piles of clothes on the floor? Do…
you wish you knew what policies your workplace could offer so everyone can think more clearly and feel better at work? Or maybe you've felt confused about which ideas even deserve your attention right now? You're not alone. And if you are ready for a change, this book is for you.Coming from a public health expert who spent over two decades designing health initiatives around the world, Decluttered is a mindful exploration of how and why clutter manifests in our lives–and what we can do about it. Jenny Albertini invites readers to explore decluttering from personal and empathetic angles while acknowledging how clutter does not only manifest as "stuff" in our homes, but also in our relationships and in our everyday lives. Blending stories and science with writing prompts and creativity exercises, this book will motivate readers to examine their relationship to their surroundings while reducing clutter for their health, in their homes, in their workplaces, and beyond. Jenny shares her own transformative journey of working in clinics in Africa and training under Marie Kondo, along with inspirational moments with clients from her years as professional organizer. Decluttered will leave its readers feeling: • Enlightened about underlying health issues related to clutter; • Aware of what to prioritize for their decluttering journey; and • Ready to take tangible steps that improve their work lives, home environments, and relationships.A refreshing addition to the well-being and home genres, Decluttered helps to reduce shame and supports readers to transform their cluttered lives and spaces into foundations for healthy, balanced and intentional living.Welcome to your world, decluttered.Heart: An Owner's Guide (The Body Literacy Library)
Par Paddy Barrett. 2024
Become body literate with Heart: An Owner's Guide, the next book in The Body Literacy Library, a helpful series that…
will break down heart health for a new generation of readers.Heart: An Owner's Guide is an informative, practical, and engaging introduction to all aspects of heart health to live well and longer. Find the key to a long, healthy life and your cardiac risk.Author Dr Paddy Barrett is an engaging and media-friendly Consultant Cardiologist specializing in preventative health care. He translates medical jargon into simple, straightforward prose, answering frequently asked patient queries, such as Should I take aspirin? Are heart attacks hereditary? Is red wine healthy? And much more.In this book, you can find:-Easy-to-follow science and lifestyle advice with simple Q&As. -Illustrations with data-driven images that show how certain lifestyle choices impact your health.-Best tips to help you know how to best care for your body and heart.-Chapters that outline the vital organ and how it works, risks for heart problems, and what to do to improve heart health. From what you should eat (or not) and exercising smarter to why stress is as dangerous as smoking, this hard-working book applies science to the everyday, with simple illustrations, checklists, FAQs, and myth busters, all supported by the latest medical research. Heart: An Owner's Guide won't just help you understand your body better.