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Don Mills: From Forests and Farms to Forces of Change
Par Scott Kennedy. 2013
How Toronto’s own city farms were crowded out First settled in the early nineteenth century, the area now known as…
Don Mills retained its rural character until the end of the Second World War. After the war, population growth resulted in pressure to develop the area around Toronto and, in a relatively short time, the landscape of Don Mills was irreparably altered. Today, the farms are all gone, as are almost all of the barns and farmhouses. Fields and forests have been replaced by the industries, homes, and shops of Canada’s “first subdivision.” In Don Mills: From Forests and Farms to Forces of Change, author Scott Kennedy remembers Don Mills as it was and takes great care to make sure that the farms and farmers are not forgotten.Careless at Work: Selected Canadian historical studies
Par J M S Careless. 1996
This sampling of the work of J.M.S. Careless in the area of Canadian historical studies was selected by the eminent…
scholar himself, and represents much of his finest work. The collection spans the years from 1940 to 1990 in the long and distinguished career of one of Canada’s best-known historians. In Careless’s own words, History is dated. Its very claim is that the past does not fade into nothing but continues to matter, whether or not the purely present-minded are able to recognize that basic fact. These essays cover the main lines of Careless’s career in Canadian scholarship. The collection is divided into four general subject areas each covering a main preoccupation in a distinguished career of over forty years. The first section concentrates on the earliest theme in his writing, George Brown and his times. The second centres on exploring various aspects of frontierism and metropolitanism in Canadian history. The third part deals with cities and regions focusing particularly on the West and nineteenth century Ontario. The final section picks up the threads of other themes including limited identities Canada and multiculturalism.Loyal Service: Perspectives on French-Canadian Military Leaders
Par Lieutenant-General J H P M Caron, Roch Legault, Colonel Bernd Horn. 2007
French Canadians have a long, proud history of serving their nation. From the earliest beginnings, French Canadians assisted in carving…
out and defending the nascent country. They were critical as defenders and as allies against hostile Natives and competing European powers. In the aftermath of the conquest, they continued, albeit under a different flag, to defend Canada. Loyal Service examines the service of a number of French-Canadian leaders and their contributions to the nation during times of peace, crisis, and conflict spanning the entire historical spectrum from New France to the end of the twentieth century.My Brother's Keeper: African Canadians and the American Civil War
Par Bryan Prince. 2015
The story of African Canadians who fled slavery in the United States but returned to enlist in the Union forces…
during the American Civil War. On New Year’s Eve in 1862, blacks from across British North America joined in spirit with their American fellows in silent vigils to await the enactment of President Lincoln’s Emancipation Proclamation. The terms declared that slaves who were held in the districts that were in rebellion would be free and that blacks would now be allowed to enlist in the Union Army and participate in the civil war that had then raged for more than a year and a half. African Canadians who had fled from the United States had not forgotten their past and eagerly sought to do their part in securing rights and liberty for all. Leaving behind their freedom in Canada, many enlisted in the Union cause. Most served as soldiers or sailors while others became recruiters, surgeons, or regimental chaplains. Entire black communities were deeply affected by this war that profoundly and irrevocably changed North American history.Treatment of Thyroid Tumor
Par Hitoshi Noguchi, Takahiro Okamoto, Yasuhiro Ito, Hiroshi Takami, Akira Yoshida. 2012
Creating clinical guidelines is a modern trend. Published studies pertaining to a given theme are collected, their credibility evaluated, and…
then treatment options in the form of evidence-based guidelines are offered. There are a number of guidelines for the treatment of thyroid tumors that have established positions in clinical practice in North America and in Western European countries. In Japan, however, where radioisotope facilities are of limited availability, treatment plans for differentiated thyroid cancer differ considerably from those of America and Europe, and the associated clinical guidelines need modification before they can be adopted. In addition, although thyroid tumor is a common disease in endocrine practice, its management can differ even among specialists. Thus, a Japanese clinical guideline for the treatment of thyroid tumor was desired by many clinicians. As a combination of evidence-based and consensus-based guidelines for the treatment of thyroid tumor, this book offers alternatives to conventional approaches in the West. Ultimately, the authors hope the guideline will lead to the best possible treatment for patients all over the world in the not-distant future.Everything You Need to Know to Manage Type 2 Diabetes: Simple Steps for Surviving and Thriving with the Low GI Plan
Par Kaye Foster-Powell, Jennie Brand-Miller, Stephen Colagiuri, Alan Barclay. 2007
A practical, easy-to-use guide to help you manage type 2 diabetes or prediabetes If you are one of the millions…
of people living with diabetes or prediabetes, you may feel like you're inundated with information on how to manage your condition. The good news is that we now know a lot more about managing diabetes or reducing your risk of developing it--and here, the world's foremost glycemic index experts share their wisdom. Rather than blind you with science or swamp you with facts, Everything You Need to Know to Manage Type 2 Diabetes sets out clearly and simply what you need to eat and do to help you: Reduce your risk of developing diabetes Improve your insulin sensitivity and your cardiovascular health Keep your blood glucose levels, blood pressure, and blood fats under control Reduce your body fat and maintain a healthy body With tips and strategies for working with your doctor, the most recent info on medications, and guidance on the best foods to eat (at home or at a restaurant), Everything You Need to Know to Manage Type 2 Diabetes offers uncomplicated, straightforward advice to help you survive--and thrive.Low GI Diet: Managing Type 2 Diabetes
Par Kaye Foster-Powell, Jennie Brand-Miller. 2014
The revised edition of the essential handbook on how to reduce the health risks posed by Type 2 Diabetes -…
from the team behind the internationally bestselling Low GI series. Are you living with type 2 diabetes or pre-diabetes and trying to manage your condition? In Australia and New Zealand alone diabetes and pre-diabetes affect 1 in 4 people. Every day nearly 300 people, including children, develop type 2 diabetes and for every person diagnosed with diabetes there's someone else with undiagnosed diabetes. The good news is that we now know a lot more about managing diabetes or reducing your risk of developing it. Low GI Diet: Managing Type 2 Diabetes cuts through the confusion of conflicting advice and sets out clearly and simply what you need to eat and do to help you: reduce your risk of developing diabetes; improve your cardiovascular health; keep your blood glucose levels, blood pressure and blood fats under control; and maintain a healthy body. This book is a practical guide to help you manage your diabetes or pre-diabetes with diet and lifestyle from the highly qualified, specialist team of authors led by world Low GI authority Professor Jennie Brand-Miller. It shows what you can do for yourself - and why. Best of all, this information is good advice for everyone in your family, not just you.Well of Lies
Par Colin Perkel. 2002
This is the story of a system that failed utterly, at almost every level, and with fatal effect. People died,…
hundreds of others were made horribly sick, and for days, no one knew what was happening, or why. There were rumours about the water, but the Public Utilities Commission blandly assured callers that the water was okay. Which left investigators trying to figure out if the problem was tainted food - or something else.Colin Perkel was among the first reporters to visit Walkerton when word finally got out that the water was poisoned. Using the interviews he conducted and the testimony given to the Walkerton Inquiry, Perkel has pieced together an authoritative and riveting account of the tragedy. He tells the story from the point of view of the people who lived through it. He shows how the virtues of a small town - its closeness, loyalty, tradition, and sense of community - contributed to the disaster. He shows how two brothers, Stan and Frank Koebel, were sustained by those virtues despite their own limitations. He provides a day-by-day account of the epidemic itself, the moments of heroism and good sense, and the instances of incompetence, wilful blindness, and plain stupidity.A few heroes do emerge: the pediatrician who was thoughtful and worried enough to raise the alarm; the investigator who worked feverishly through a holiday weekend to find the source of the poison; even perhaps the reporter at the local radio station who broadcast the boil-water advisory. Neither the politicians - at any level -nor the bureaucrats in the Department of Environment and the health ministry come out very well. But Colin Perkel never loses sight of the fact that this story is about real people. And his account of what happened is always set in the context of the complicated lives of the people who lived through it. There are no villains in this story, but only flawed humans.This is a superb piece of reporting. It deals with a tragedy that might have occurred - and might occur again - in virtually any community in Canada.Diabetes and Cardiovascular Disease
Par Francesco Paneni, Francesco Cosentino. 2015
This book provides a practical hands-on approach to the management of patients with diabetes and cardiovascular disease, with original and…
up-to-date coverage of a variety of aspects of emerging clinical importance. Practical advice is offered on diagnosis, risk stratification, management of cardiovascular risk factors and available drug therapies. Appropriate myocardial revascularization strategies are explained and the current state of knowledge is documented regarding target-led multifactorial treatment and the management of acute coronary syndromes, heart failure, and cerebrovascular disease. New algorithms for diagnosis and treatment are presented and to ensure ease of reference each chapter includes a box with practical recommendations as well as informative color illustrations and tables. The handbook will be of value for all cardiologists and diabetologists and will be especially helpful for young cardiologists, who are ever more frequently confronted by patients with diabetes and cardiovascular disease.Genetic Damage in Human Spermatozoa
Par Monica Muratori, Elisabetta Baldi. 2014
There are several types of damage that can be found in the male gamete. Genetic damage in spermatozoa can originate…
during spermatogenesis, or it can originate during transit in both male and female genital tracts. Damage can also be due to ageing, environmental or iatrogenic conditions, as well as to the protocols to cryopreserve and to select spermatozoa in assisted reproduction techniques. The purpose of this book is to provide a comprehensive resource for all possible DNA damages in sperm, the relation to fertility and infertility, and possible transgenerational heritable effects.Thymic Development and Selection of T Lymphocytes
Par Thomas Boehm, Yousuke Takahama. 2014
The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place.…
Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.Obesity and Breast Cancer
Par Kristy A. Brown, Evan R. Simpson. 2014
Obesity is a risk factor for breast cancer in older women. A number of adipose-derived and obesity-related factors have been…
shown to affect tumour cell growth. These include adipokines, insulin, IGF-1 and oestrogens. The majority of obesity-related postmenopausal breast cancers are oestrogen-dependent. Since the ovaries no longer produce oestrogens after menopause, and that circulating levels are negligible, it is evident that it is the oestrogens produced locally within the breast adipose that are responsible for the increased growth of breast cancer cells. Aromatase is the enzyme that converts androgens into oestrogens and its regulation is dependent on the activity of a number of tissue-specific promoters. Targeting oestrogen biosynthesis in obesity may be useful for the prevention of breast cancer. Aromatase inhibitors are efficacious at treating postmenopausal breast cancer and recent studies suggest that they may also be useful in the prevention setting. However, these compounds inhibit the catalytic activity of aromatase and as a consequence lead to a number of undesirable side-effects, including arthralgia and possible cognitive defects due to inhibition of aromatase in the bone and brain, respectively. Novel therapies, such as those employed to treat obesity-associated disease, including anti-diabetics, may prove successful at inhibiting aromatase specifically within the breast. This SpringerBrief will explore all of these issues in depth and the authors are in a unique position to write about this topic, having extensive experience in the field of aromatase research.Our Intellectual Strength and Weakness: 'English-Canadian Literature' and 'French-Canadian Literature'
Par Thomas Guthrie Marquis, Clara Thomas, Douglas Lochhead, John George Bourinot, Camille Roy. 1973
These three works, displaying marked differences in purpose, tone, and effect, are all classics of Canadian literary and cultural criticism.John…
George Bourinot was a man of letters, an Imperialist, and a biculturalist, who was confident of his knowledge of the Canadian identity and felt it to be his public mission to align reality with his own personal vision. Writing in 1893 to the élite represented by the members of the Royal Society, he described his work as 'a monograph on the intellectual development of the Dominion,' describing 'the progress of culture in a country still struggling with the difficulties of the material development of half a continent.'Two decades later, Thomas Guthrie Marquis and Camille Roy wrote what were, in contrast, specialized assignments, contributions to the compendium history, Canada and Its Provinces (1913). Addressing a far larger audience, and treating a vastly enlarged body of Canadian literature, their work comes much closer to contemporary scholarship, with greater clarity, organization, and sheer bulk of information, but with the loss of some of the charm and assurance of Bourinot's wide sweep. In further contrast to Bourinot's determined biculturalism and will to unity, Roy and Marquis' essays display vivid differences in the emotional allegiances and convictions of the founding cultures. Marquis starts by asking the question, 'Has Canada a voice of her own in literature distinct from that of England?'; Roy treats French-Canadian literature in its Roman Catholic contexts.The Cleveland Clinic Manual of Dynamic Endocrine Testing
Par Ahmet Bahadir Ergin, A. Laurence Kennedy, Manjula K. Gupta, Amir H. Hamrahian. 2015
Developed via a peer review process that included 25 experienced endocrinologists and utilizing the best current evidence, The Cleveland Clinic…
has created a practical set of protocols for over 25 commonly used dynamic endocrine tests. The cornerstone of clinical endocrinology, these evidence-based protocols play an important role in clinical decision-making and are important element of billing and compliance with high quality standards. Included here are various tests for pituitary and adrenal disorders, thyroid disorders, and glucose metabolism and pancreatic disorders, presented systematically with indications, preparation, materials needed, precautions, procedure, interpretation, and caveats. Filling the gap left by a lack of national guidelines, The Cleveland Clinic Manual of Dynamic Endocrine Testing is an up-to-date practical guide for endocrinologists, nurses, and their staff, inside or outside of the US, who need to perform and interpret dynamic endocrine testing in their everyday practice, as well as medical students, residents and fellows who have interest in endocrinology.Stem Cell Therapy in Lysosomal Storage Diseases
Par Jaap Jan Boelens, Robert Wynn. 2013
Stem Cell therapy for lysosomal diseases (LSDs) is developing rapidly. This volume discusses the history, current practice and future perspectives…
of stem cells in inborn errors of metabolism (IEM) and provides an international perspective on progress, limitations, and future directions (e. g. gene therapy, iPS, ES) in the field. Beginning with an overview of these diseases, the book covers the breadth of this topic from treatment options, bone marrow transplantation, and alternative treatment options, through long-term outcomes and future perspectives.Therapeutic Perspectives in Type-1 Diabetes
Par Prachi Singh, Ganesh R Kokil, Karnaker R Tupally, Kingshuk Poddar, Aaron Tan, Venky Venkatesan, Harendra S. Parekh, Giorgia Pastorin. 2016
This book provides critical insights into and appraisals ofrecent breakthroughs in type 1 diabetes modulation, with a particular emphasison the…
potential impact of current prevention and treatment strategies. It alsodiscusses recent successes and failures in clinical trials. Presenting ancomprehensive overview of the disease, it is especially useful for newcomers inthe field. It also includes illustrations, which make it easy for the reader tograsp the basic concepts involved. Furthermore, the tables include concise andeasy-to-understand information on current clinical trials.Diabetes Management in Clinical Practice
Par Tahseen A. Chowdhury. 2014
At a time when clinicians are bombarded with masses of clinical information from numerous sources, and the wide variety of…
changes/advances in diabetes management, there is a need for a concise, easy-to-read book that provides an up-to-date review of the major advances in management of diabetes, with an evidence-based approach. This book is a collection of short chapters, each focused on a subject related to the management of diabetes and its complications. The chapters are written by acknowledged experts in the field, who are also clinicians dealing with diabetes on a day-to-day basis. The text is highly evidence based and well referenced with reviews of relevant trials. It includes the latest developments in diabetes management, prospects for future therapies and avenues of research, as well as therapies currently undergoing clinical trial. In order to facilitate ease of reading, it has a user-friendly appearance, with multiple headings, illustrations and summary boxes. The primary audience is clinical, including all healthcare professionals involved in the management of diabetes and its complications. This encompasses diabetologists and endocrinologists, family practitioners with an interest in diabetes, specialist nurses, dietitians and podiatrists.Glycemic Control in the Hospitalized Patient
Par Lillian F. Lien, Leonor Corsino, Mark N. Feinglos, Mary E. Cox. 2011
Glycemic Control in the Hospitalized Patient: A Comprehensive Clinical Guide is a unique, practical resource for health care providers dealing…
with hyperglycemia in the inpatient setting. Outlining a hands-on approach used by the Duke University Inpatient Diabetes Management team, the book discusses a wide range of scenarios that occur while treating patients with hyperglycemia, including challenging circumstances such as steroids and tube feeding regimens. Special emphasis is given to insulin therapy. The chapters are written by a group of health care providers with extensive, pioneering experience in hyperglycemia control in the inpatient setting at the Duke University Medical Center. The book includes the most up-to-date scientific evidence and information and is addressed to not only hospitalists and general internists but also endocrinology fellows, residents, nurse practitioners, nurses, and other primary care practitioners who treat patients in the inpatient setting. The focus is clearly on practical, patient-care topics. Glycemic Control in the Hospitalized Patient: A Comprehensive Clinical Guide is a first-of-its kind, comprehensive guide to state-of-the-art inpatient glycemic management.Hormones, Intrauterine Health and Programming
Par Jonathan R Seckl, Yves Christen. 2014
The authors address in particular the role of hormones and their links with other maternal environmental mediators in developmental programming.…
The crucial nature of the placenta as an interface and target between maternal and foetal environments is addressed. Emphasis is made on the emerging science of epigenetics as a potential explanation for how environmental events that occur during brief windows of development may exert effects that impact upon somatic cells through many rounds of mitosis for much of the life span of the subsequent organism.Managing Diabetic Nephropathies in Clinical Practice
Par George L. L. Bakris, Allison Hahr, Romesh Khardori, Daisuke Koya, Mark Molitch, Friedrich C. C. Prischl, Guntram Schernthaner, Bijin Thajudeen. 2017
An overview of the diagnosis, treatment, and long-term management of diabetic-related kidney disease in clinical practice. Includes an evidence-based discussion…
of currently available and experimental drug therapies currently in development, guided by international consensus guidelines. Ideal for physicians, medical trainees, nurses and other medical professional that regularly screen and treat patients with all types of diabetes.