Service Alert
Entretien du site web le 24 avril à 22h HAE
Le site web sera indisponible le 24 avril à 22h HAE pour 15 minutes en raison de travail d'entretien prévu.
Le site web sera indisponible le 24 avril à 22h HAE pour 15 minutes en raison de travail d'entretien prévu.
Articles 42361 à 42380 sur 48793
Par Esther Mavengano, Tobias Marevesa, and Ernest Jakaza. 2023
This comprehensive book brings together reflections, lessons and insights relating to the post Covid-19 era in Zimbabwe. The outbreak of…
the COVID-19 pandemic has immensely affected all facets of humanity globally. Its impact on Zimbabwe is evident through its effect on socio-economic and education systems, politics, religion, infrastructural development, and health delivery systems. This book provides scholarly introspections into the lessons drawn from the pandemic in an effort to re-imagine the future possibilities of public health in Zimbabwe and beyond. Providing a platform for research that seeks to re-think global public health matters from a Decolonial school of thought, the book asks questions such as: What is the role of religion, linguistics, communication, education, economics, politics, and science in preparing Zimbabwe for possible future pandemics? How can the lessons drawn from the pandemic inform scholars to re-imagine the future trajectories of the country in the various domains? How can researchers evaluate the power and economic dialectics of COVID-19, navigate the tumultuous challenges generated, and come up with appropriate systems for future pandemics? Offering a realistic picture of the post COVID-19 era in Zimbabwe, the book will be a key resource to students and researchers across the fields of political communication, science communication, decolonial discourse, language and culture, as well as African Studies more broadly.Par Katherine Hirschfeld, Kirsten De Beurs, Brad Brayfield, Ani Melkonyan-Gottschalk. 2023
This Open Access book uses Mary Kaldor’s concept of “New Wars” to explore how ethnic conflict reshaped the social and…
environmental landscape of the Southern Caucuses following the collapse of the Soviet Union. It relies on remote sensing data and qualitative historical research to explore how armed conflict between non-state actors generated the region’s largest epidemic of P. vivax malaria since the 1960s. This book is an important addition to the literature on the Karabakh conflict and conflict studies more broadly because the infectious disease outbreaks associated with warfare often kill more people than the armed conflicts themselves. Warfare itself has also changed dramatically since the collapse of the USSR, and the Karabakh conflict provides an excellent case study of the way “New Wars” transform the natural and social environment to facilitate outbreaks of preventable disease. This extended case study will be useful to researchers from a variety of academic disciplines, including medical anthropology, geography, conflict studies, disease ecology, global health and public health. It also reveals the fragility of twentieth century malaria control in temperate regions and will assist in predictive modeling for future outbreaks.Par Élodie Giroux, Francesca Merlin, Yohan Fayet. 2023
Research on the relationship between health and the environment in a postgenomic context is increasingly aimed at understanding the various…
exposures as a whole, simultaneously taking into account data pertaining to the biology of organisms and the physical and social environment. Exposome research is a paradigmatic case of this new trend in environmental health studies. This book takes a multidisciplinary approach focusing on the conceptual, epistemological, and sociological reflections in the latest research on environmental and social determinants of health and disease. It offers a combination of theoretical and practical approaches and the authors are scholars from a multidisciplinary background (epidemiology, geography, philosophy of medicine and biology, sociology). Crucially, the book balances the benefit and cost of the integration of biological and social factors when modelling aetiology of disease.One out of every six patients in the United States is treated in a Catholic hospital that follows the policies…
of the U.S. Conference of Catholic Bishops. These policies prohibit abortion, sterilization, contraception, some treatments for miscarriage and gender confirmation, and other reproductive care, undermining hard-won patients’ rights to bodily autonomy and informed decision-making. Drawing on rich interviews with patients and providers, this book reveals both how the bishops’ directives operate and how people inside Catholic hospitals navigate the resulting restrictions on medical practice. In doing so, Bishops and Bodies fleshes out a vivid picture of how The Church’s stance on sex, reproduction, and “life” itself manifests in institutions that affect us all.Par Marieke Bigg. 2023
'A vital subject that needs to be discussed -KATY HESSEL, AUTHOR OF THE STORY OF ART WITHOUT MEN'A valuable sociological…
perspective on women's bodies and health and an even more valuable (and optimistic) view of a better future for all.' GINA RIPPON'Asking all the right questions about the treatment of women's bodies and more importantly, answering them. Punchy, fascinating and vital.' RACHEL PARRIS'A brilliant book.' HELEN PANKHURST'[Marieke] is balanced in her evidence analysis, forensic in her research.' TELEGRAPHThe idea that medicine is gender-neutral is a myth. This isn't inflammatory rhetoric; it's simply true. From the way pain is felt, to how heart attacks are diagnosed, to the very role society plays in the health of the body, the medical landscape in place today is one that was designed for, and by, men. This book is about all the ways medicine is not gender-neutral, from research to treatment to diagnosis. Throughout history, flawed mindsets have paved the way for sub-par treatment, and the prevailing attitudes that still exist today have had terrible repercussions for women and their bodies. Blending fascinating examples with historical and cultural context, and reflecting on her own personal experience with healthcare, Dr Marieke Bigg explores how women's bodies have been ignored, misunderstood and misdiagnosed, whilst keeping an eye to a better future. This is a sharp and honest must-read, and an empowering tool for anyone committed to making this world safer to navigate for all.Par Leszek A. Maciaszek, Maurice D. Mulvenna, Martina Ziefle. 2023
This book constitutes the refereed post-conference proceedings of the 7th and the 8th International Conference on Big Data Technologies and Applications, ICT4AWE 2021…
and ICT4AWE 2022, held in April 24–26, 2021 and April 23–25, 2022. Due to COVID-19 pandemic both conferences were held virtually.The 21 full papers of ICT4AWE 2021 and ICT4AWE 2022 were selected from 80 submissions and present all big data technologies, such as Aging Well - Social and Human Sciences Perspective; Telemedicine and Independent Living; Digital Health and e-health.Par Márcia C. Breitkreitz, Hector C. Goicoechea. 2023
Written by twenty-five authors from academia, pharmaceutical industry and Pharmacopeias worldwide, this monograph covers the fundamentals and applications of Quality…
by Design (QbD) and Analytical Quality by Design (AQbD) in a practical and didactic manner. The book starts by describing the motivation and the urgent need for the implementation of the QbD framework in pharmaceutical development, along with the definition of its major elements: Quality Target Product Profile (QTTP), Critical Quality Attributes (CQAs), Critical Process Parameters (CPPs), Critical Material Attributes (CMAs) and the importance of using multivariate methods of Design of Experiments (DOE). The concept of life cycle and regulatory perspectives are discussed. Three chapters are entirely dedicated to DOE theory from screening to optimization designs. Moreover, a comprehensive discussion on modelling and data treatment is presented. Practical aspects of QbD and DOE for pharmaceutical product and process of different dosage forms is included, as well as a practical guide of the input process variables, material attributes, intermediate, and final quality attributes for the most representative pharmaceutical processes. Analytical Quality by Design (AQbD) is also deeply explored, including risk analysis, definitions of Analytical Target Profile (ATP), Method Operable Design Region (MODR) and the life cycle approach, taking into account the compendial and regulatory perspectives. A detailed example of a new chromatographic method for the quality control of a pharmaceutical topical product based on the AQbD procedure is shown. Finally, advanced statistical approaches and DOE methods for extraction studies of bioactive compounds are also presented. The vast amount of information offered in this book provides a comprehensive perspective on QbD, AQbD and DOE principles, essential tools for modern pharmaceutical and analytical development.Updating and expanding the scope of topics covered in the previous edition, Percutaneous Absorption: Drugs, Cosmetics, Mechanisms, Methods, Fifth Edition…
supplies new chapters on topics currently impacting the field including cutaneous metabolism, skin contamination, exposure to protein allergens, in vitro absorption methodology and the percutaneous absorption of chemical mixtures. Complete with studies on the role of the skin as a key portal of entry for chemicals into the body, this book serves as a detailed reference source for recent advances in the field, as well as an experimental guide for laboratory personnel. Key Features: Details in vivo and in vitro methods for measuring absorption, dermal decontamination, mechanisms of transdermal delivery, and the relationship of transepidermal water loss to percutaneous absorption Considers a range of mathematical models, the safety evaluation of cosmetic ingredients, the absorption of hair dyes, nanoparticles for drug delivery, and other novel methods of drug delivery Discusses topics including skin metabolism, the skin reservoir, and the effects of desquamation on absorptionPar Pasquale Arpaia, Umberto Cesaro, Nicola Moccaldi, Isabella Sannino. 2022
The book presents an innovative technology based on injection of a very weak current to trace the quantity of a…
drug carried immediately after the administration. The book makes the reader familiar with the technology, from the conception through the design of the instrument, up to the preliminary clinical applications. In the first chapter, the method of transdermal drug delivery and the use of impedance spectroscopy in the dermatological field are presented. The second chapter describes a screening measurement campaign aimed at proving the feasibility of the assessment method and identifying the bandwidth of interest. The prototyping, validation and characterization of an instrument to measure the amount of drug delivered (DUSM: Drug Under Skin Meter) are presented in chapter three. In the fourth chapter three experimental campaigns, based on the electrical analysis of the biological tissue behavior due to the drug delivery, are reported: (i) laboratory emulation on eggplants, (ii) ex-vivo tests on pig ears, and finally (iii) in-vivo tests on human volunteers. In the fifth chapter a behavioral model, based on Finite Elements and Partial Differential Equation, of an impedance-based measurement system for assessing the drug released under the skin, during transdermal delivering, is proposed. The last chapter is dedicated to present a campaign in order to prove the suitability for insulin therapy applications. This book is intended for biomedical engineers, biomedical engineering students, operators working in the field of biomedical instrumentation, biotechnologists, and technicians of transdermal vehiculation.Par Agis Kydonieus. 1992
An introductory but detailed treatise which includes some 1,000 references and solved examples and end-of-chapter problems, making it useful to…
both students and practitioners. The pharmokinetics, pharmacodynamics, and biological and biopharmaceutical parameters pertinent to each route of administraPar Michael Szycher. 1995
FROM THE PREFACEThe field of medical devices represents one of the most advanced technological areas in the United States. In…
1991, over 12 million Americans had at least one medical device; fixation devices had the highest incidence, followed by contact lens use and lens implants and, lastly, artificial joints. The public has come to expect that medical devices will alleviate maladies and/or conditions that were not treatable fifty years ago. It is hard to believe that the first pacemaker was invented in the 1950s, the first artificial heart valve in 1952, and the first artificial hip replacement was performed in 1954. In 1992, the medical device industry exported a total of $6.9 billion, while the country imported a total of $3.9 billion, representing a $3.0 billion trade surplus. Medical devices are among the most regulated products in the world. The FDA maintains a constant vigil over medical device manufacturers and importers; even medical device definitions are subject to official scrutiny. Title 21 of the Code of Federal Regulations publishes these definitions, but the definitions are spread over several medical specialty areas and are, thus, difficult to find. This book attempts to bring a measure of order by providing an alphabetical listing of officially defined devices.Par Sundaram Gunasekaran. 2022
This book presents the state-of-the-art advances and applications of nanozymes, the recently developing branch of enzymology that synthesizes and uses…
nanomaterials that mimic the function of traditional enzymes. During the past decade, the study of nanozymes has grown rapidly. Several new nanomaterials that exhibit enzymatic actions have been identified, along with new applications for their practical use. This book draws upon the work of experts from around the world and provides an in-depth analysis and cutting-edge overview of nanozymes, with an eye toward their present and future applications. Chapters are arranged in a logical order to provide physio-chemical characterization of nanozyme and basic mechanisms of their enzymatic actions. Focusing on current limitations of nanozymes and their reaction kinetics, the book presents a comprehensive discourse on nanozyme engineering that includes possible surface modifications to enhance nanozyme effectiveness. It also focuses on traditional and novel nanozyme applications, such as biosensing, drug delivery, and disease therapy, as well as their use as antibacterials. An important addition in this book is the summary of emerging literature on nanozyme toxicology. This book is intended as a ready reference for advanced undergraduate and graduate students doing research in nanotechnology; materials science; chemistry; and chemical, biological, biomedical, and food engineering. Research and development scientists, engineers, and technologists working in the chemical and biological/biomedical industries will gain much from the materials in this book for their industry practice. Presents a comprehensive discourse on nanozyme engineering that includes possible surface modifications to enhance nanozyme effectiveness. Discusses metal organic frameworks as nanozymes. Reviews on traditional and novel nanozyme applications, such as biosensing, drug delivery, disease therapy, and their use as antibacterials. Examines nanozyme toxicology. Dr. Sundaram Gunasekaran is a Professor in the Department of Biological Systems Engineering at the University of Wisconsin–Madison.With contributions from leading international researchers, this second edition of Electrical Impedance Tomography: Methods, History and Applications has been fully…
updated throughout and contains new developments in the field, including sections on image interpretation and image reconstruction. Providing a thorough review of the progress of EIT, the present state of knowledge, and a look at future advances and applications, this accessible reference will be invaluable for mathematicians, physicists dealing with bioimpedance, electronic engineerers involved in developing and extending its applications, and clinicians wishing to take advantage of this powerful imaging method. Key Features: Fully updated throughout, with new sections on image interpretation and image reconstruction Overview of the current state of experimental and clinical use of EIT as well as active research developments Overview of related research in geophysics, industrial process tomography, magnetic-resonance and magnetic-inductionimpedance imagingPar Eduardo Bruera. 2021
This new edition provides the essential clinical guidance both for those embarking upon a career in palliative medicine and for…
those already established in the field. A team of international experts here distil what every practitioner needs to know into a practical and reliable resource.Par Eric Jungermann, Norman O.V. Sonntag. 1991
This book comprehensively covers the chemical and physical properties and manufacturing and handling procedures of glycerine and the use of…
this material in cosmetic and personal care products and in other industrial areas such as testing laboratories and manufacturing and marketing sectors.This book should prove valuable in relieving stress and anxiety, especially important nowadays as the journey from diagnosis to cure…
or death is longer due to improvements in medical treatments. Healthcare workers and the general public worldwide would benefit as death is universal. The writing style is engaging and easy to read, yet highly informative. I would recommend this book to my patients and their families and friends. Dr. Suzanne Ward BMED FRAGP General Medical Practitioner Canberra, Australia This easy to read manual is invaluable reading following a life-threatening medical diagnosis. It is a comprehensive, clear and concise guide which can help reduce stress and improve healing potential. Written by a Registered Nurse (ret) who worked in the USA, UK, and Australia, she discusses why expressing fears soon after diagnosis can be beneficial for healing. Whatever the diagnosis, Cancer, Heart Attack, Stroke, Parkinson’s Disease, etc., you, your family, friends and colleagues will have worries and fears about your future. Reducing fears and stress early on gives more positive room for healing. This manual is indispensable for Doctors and Nurses, encouraging them to learn why and how discussing fears early on is a positive healing opportunity rather than being negative. Various complementary therapies are discussed to use in combination with traditional medicine, maximizing healing opportunities. While we plan for births and marriages, we find it difficult to talk and plan for our deaths, even though none of us escapes it! This book provides tools and suggestions for preparing Wills, Advanced Directives, and listing assets and wishes at whatever age, the sooner the better. Being prepared makes life so much easier for all. Learn how to live a more content, peaceful life alongside your family, friends, neighbors and globally. Life is not a dress rehearsal. Learn how to live fully NOW.Par Dinesh Singh. 2021
Postharvest Handling and Diseases of Horticultural Produce describes all the postharvest techniques, handling, pre-cooling, postharvest treatment, edible coating and storage…
of the horticultural produce available to handle perishable horticultural food commodities, covering the areas of horticulture, agricultural process engineering, postharvest technology, plant pathology and microbiology. Postharvest diseases of major fruits and vegetables, with their causal agents, are described. The integrative strategies for management of postharvest diseases include effectively inhibiting the growth of pathogens, enhancing the resistance of hosts and improving environmental conditions, with results that are favourable to the host and unfavourable to the pathogen growth including biotechnological approaches. Adopting a thematic style, chapters are organized by type of treatment, with sections devoted to postharvest risk factors and their amelioration. The chapters are written by experts in the fields of plant pathology, horticulture, food science etc., and core insights into identifying and utilizing appropriate postharvest options for minimizing postharvest losses and enhancing benefits to end-users are provided. Features Presents the most recent developments in the field of postharvest handling technologies and diseases in a single volume Includes postharvest diseases of cut flowers, fruits, vegetables and tuber crops. Appropriate for students, researchers and professionals Written by experts and can be used as a reference resourceThis book is about building platforms for pandemic prediction. It provides an overview of probabilistic prediction for pandemic modeling based…
on a data-driven approach. It also provides guidance on building platforms with currently available technology using tools such as R, Shiny, and interactive plotting programs. The focus is on the integration of statistics and computing tools rather than on an in-depth analysis of all possibilities on each side. Readers can follow different reading paths through the book, depending on their needs. The book is meant as a basis for further investigation of statistical modelling, implementation tools, monitoring aspects, and software functionalities. Features: A general but parsimonious class of models to perform statistical prediction for epidemics, using a Bayesian approach Implementation of automated routines to obtain daily prediction results How to interactively visualize the model results Strategies for monitoring the performance of the predictions and identifying potential issues in the results Discusses the many decisions required to develop and publish online platforms Supplemented by an R package and its specific functionalities to model epidemic outbreaks The book is geared towards practitioners with an interest in the development and presentation of results in an online platform of statistical analysis of epidemiological data. The primary audience includes applied statisticians, biostatisticians, computer scientists, epidemiologists, and professionals interested in learning more about epidemic modelling in general, including the COVID-19 pandemic, and platform building. The authors are professors at the Statistics Department at Universidade Federal de Minas Gerais. Their research records exhibit contributions applied to a number of areas of Science, including Epidemiology. Their research activities include books published with Chapman and Hall/CRC and papers in high quality journals. They have also been involved with academic management of graduate programs in Statistics and one of them is currently the President of the Brazilian Statistical Association.Par Jianrong Wu. 2022
Single-Arm Phase II Survival Trial Design provides a comprehensive summary to the most commonly- used methods for single-arm phase II…
trial design with time-to-event endpoints. Single-arm phase II trials are a key component for successfully developing advanced cancer drugs and treatments, particular for target therapy and immunotherapy in which time-to-event endpoints are often the primary endpoints. Most test statistics for single-arm phase II trial design with time-to-event endpoints are not available in commercial software. Key Features: Covers the most frequently used methods for single-arm phase II trial design with time-to-event endpoints in a comprehensive fashion. Provides new material on phase II immunotherapy trial design and phase II trial design with TTP ratio endpoint. Illustrates trial designs by real clinical trial examples Includes R code for all methods proposed in the book, enabling straightforward sample size calculation.Par Uma Patnaik. 2021
Practice of otology today, requires a contemporary knowledge base, coupled with concurrent skill sets, and tempered with familiarity of the…
technological advances. This manual has been designed to address these three domains, making it a ready reference to guide specialists on the standards of care in practice. The chapters explore the current concepts, with a background of past practices, touching upon the basics of anatomy and physiology before dealing with clinical conditions and their management, covering specific clinical scenarios to develop a patient-oriented approach in the readers using evidence-based guidelines. Key Features Focuses on clinical scenarios, decision making and current concepts, providing patient-based scenarios which are relevant to all surgeons practicing otology. Serves as a companion guide to standards of care for Otologists, neurotologists, otorhinolaryngologists, young surgeons and senior residents. Discusses various controversies in this field and provides a general consensus/guideline which is likely to be acceptable to most practitioners